The application of the Three-Dimensional Ultra-Short Echo Time (3D UTE)pulse sequence at a high magnetic field for visualization of the distribution of
19F loaded theranostic core-shell nanocapsules with Nafion
® (1,1,2,2-tetrafluoroethene; 1,1,2,2-tetrafluoro-2- [1,1,1,2,3,3-hexafluoro-3-(1,2,2-trifluoroethenoxy)propan-2-yl] oxyethanesulfonic acid) incorporated into the shell is presented. The
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The application of the Three-Dimensional Ultra-Short Echo Time (3D UTE)pulse sequence at a high magnetic field for visualization of the distribution of
19F loaded theranostic core-shell nanocapsules with Nafion
® (1,1,2,2-tetrafluoroethene; 1,1,2,2-tetrafluoro-2- [1,1,1,2,3,3-hexafluoro-3-(1,2,2-trifluoroethenoxy)propan-2-yl] oxyethanesulfonic acid) incorporated into the shell is presented. The nanocarriers were formed via the layer-by-layer technique with biodegradable polyelectrolytes: PLL (Poly-L-lysine), and with Nafion
®: polymer with high
19F content. Before imaging, an MR (magnetic resonance) spectroscopy and T
1 and T
2 measurements were performed, resulting in values of T
2 between 1.3 ms and 3.0 ms, depending on the spectral line. To overcome limitations due to such short T
2, the 3D UTE pulse sequence was applied for
19F MR imaging. First Nafion
® solutions of various concentrations were measured to check the detection limit of our system for the investigated molecule. Next, the imaging of a phantom containing core-shell nanocapsules was performed to assess the possibility of visualizing their distribution in the samples. Images of Nafion
® containing samples with SNR ≥ 5 with acquisition time below 30 min for
19F concentration as low as 1.53 × 10
−2 mmol
19F/g of sample, were obtained. This is comparable with the results obtained for molecules, which exhibit more preferable MR characteristics.
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