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J. Funct. Biomater. 2018, 9(1), 21; https://doi.org/10.3390/jfb9010021

Electron Beam Immobilization of Novel Antimicrobial, Short Peptide Motifs Leads to Membrane Surfaces with Promising Antibacterial Properties

1
Department of Chemistry, Biochemistry, University of Cologne, Zülpicher Str. 47a, D-50674 Cologne, Germany
2
Leibniz Institute of Surface Engineering, Permoserstr. 15, D-04318 Leipzig, Germany
3
Department of Chemistry, Organic Chemistry, University of Cologne, Greinstr. 4, D-50939 Cologne, Germany
*
Authors to whom correspondence should be addressed.
Received: 22 January 2018 / Revised: 2 February 2018 / Accepted: 22 February 2018 / Published: 27 February 2018
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Abstract

In this study, the efficacy of electron beam irradiation versus chemical coupling for yielding polyethersulfone (PES) membranes with antibacterial properties was investigated. For the surface coating, a recently discovered lead compound, IL-KKA, comprising a short peptide sequence functionalized with imidazolium groups, was used. For better integration within the membrane, several novel variants of IL-KKA were generated. Membrane immobilization was achieved using different doses of electron beam irradiation and NHS/EDC chemical coupling. Physicochemical characterization of the coated membranes was performed by water contact angle measurements, X-ray photoelectron spectroscopy, and scanning electron microscopy. Our results show that electron beam irradiation is as effective and gentle as chemical coupling using the NHS/EDC method. Moreover, it was demonstrated that the obtained membranes exhibit promising antibacterial activity against B. subtilis. In summary, the technique presented herein might be promising as a template for developing future anti-biofilm devices. View Full-Text
Keywords: biofilm formation; electron beam; antimicrobial peptides; surface modification; immobilization techniques biofilm formation; electron beam; antimicrobial peptides; surface modification; immobilization techniques
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Reinhardt, A.; Thomas, I.; Schmauck, J.; Giernoth, R.; Schulze, A.; Neundorf, I. Electron Beam Immobilization of Novel Antimicrobial, Short Peptide Motifs Leads to Membrane Surfaces with Promising Antibacterial Properties. J. Funct. Biomater. 2018, 9, 21.

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