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Open AccessArticle

Osseointegration of Titanium Implants in Onlay of Cerament™, a New Ceramic Bone Substitute

Department of Oral Pathology, Faculty of Odontology, Malmö University, Malmö SE-205 06, Sweden
Department of Orthopedics, Lund University Hospital, Lund SE-221 85, Sweden
Author to whom correspondence should be addressed.
Academic Editor: Adriana Bigi
J. Funct. Biomater. 2016, 7(1), 2;
Received: 21 September 2015 / Revised: 15 December 2015 / Accepted: 30 December 2015 / Published: 7 January 2016
The purpose was to investigate whether a new biphasic and injectable ceramic bone substitute Cerament™ that rapidly remodels to bone, may contribute to the retention of titanium implant screws during the healing period, and to analyze the pattern of bone formation around titanium implants.Titanium screws were implanted in rat tibiae and embedded with or without Cerament™ on the cortical surface. Torsional resistance was measured after 1 day, and after 6 and 12 weeks. Implant areas without bone substitute were analyzed histologically for comparison. The torsional resistance increased over time as the screws were osseointegrated. There was no difference in resistance between screws embedded in the bone substitute and control screws. The bone apposition was more pronounced on the proximal side of the screw than on the distal side. Cerament™ is capable of conducting bone growth from a cortical bone surface. The newly formed bone in this application does not significantly add to the osseointegrative strength of the implant screw, as measured by torque resistance, during the first 12 weeks. View Full-Text
Keywords: animal model; bone substitutes; histological analysis; osseointegration animal model; bone substitutes; histological analysis; osseointegration
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Truedsson, A.; Wang, J.-S.; Lindberg, P.; Warfvinge, G. Osseointegration of Titanium Implants in Onlay of Cerament™, a New Ceramic Bone Substitute. J. Funct. Biomater. 2016, 7, 2.

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