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Open AccessArticle

The Use of Thermal Techniques for the Characterization and Selection of Natural Biomaterials

1
Physique des Polymères, Institut Carnot CIRIMAT UMR5085, Université Paul Sabatier, 118 route de Narbonne, Bat 3R1B2, 31062 Toulouse Cedex, France
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LAPLACE, UMR CNRS 5213, Université Paul Sabatier, 118 Route de Narbonne, 31062 Toulouse Cedex 9, France
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Dipartimento di Scienze Biomediche Sperimentali, Università di Padova, Viale Colombo 3, 35131 Padova, Italy
*
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2011, 2(3), 230-248; https://doi.org/10.3390/jfb2030230
Received: 6 July 2011 / Revised: 30 August 2011 / Accepted: 2 September 2011 / Published: 13 September 2011
In this paper we explore the ability of thermal analysis to check elastin and collagen integrity in different biomaterial applications. Differential Scanning Calorimetry (DSC) has been used to analyze the first and second order transitions of the biological macromolecules in the hydrated and dehydrated state. First, we report the characterization of control cardiovascular tissues such as pericardium, aortic wall and valvular leaflet. Their thermal properties are compared to pure elastin and pure collagen. Second, we present results obtained on two collagen rich tissues: pericardia with different chemical treatments and collagen with physical treatments. Finally, more complex cardiovascular tissues composed of elastin and collagen are analyzed and the effect of detergent treatment on the physical structure of collagen and elastin is brought to the fore. View Full-Text
Keywords: elastin glass transition; collagen denaturation; differential scanning calorimetry; thermal stability elastin glass transition; collagen denaturation; differential scanning calorimetry; thermal stability
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Samouillan, V.; Delaunay, F.; Dandurand, J.; Merbahi, N.; Gardou, J.-P.; Yousfi, M.; Gandaglia, A.; Spina, M.; Lacabanne, C. The Use of Thermal Techniques for the Characterization and Selection of Natural Biomaterials. J. Funct. Biomater. 2011, 2, 230-248.

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