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Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties

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Chemical and Pharmaceutical Engineering Department, D. Mendeleev University of Chemical-Technology of Russia, 125480 Moscow, Russia
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Nanomaterials and Nanotechnology Department, D. Mendeleev University of Chemical-Technology of Russia, 125480 Moscow, Russia
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National Research Medical Centre of Rehabilitation and Balneology, Ministry of Health of the Russian Federation, 121099 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editors: Piotr Kurcok and Vijay Kumar Thakur
J. Funct. Biomater. 2021, 12(4), 55; https://doi.org/10.3390/jfb12040055
Received: 12 August 2021 / Revised: 27 September 2021 / Accepted: 28 September 2021 / Published: 1 October 2021
The creation of artificial biocomposites consisting of biocompatible materials in combination with bioactive molecules is one of the main tasks of tissue engineering. The development of new materials, which are biocompatible, functional, and also biodegradable in vivo, is a specific problem. Two types of products can be formed from these materials in the processes of biodegradation. The first types of substances are natural for a living organism and are included in the metabolism of cells, for example, sugars, lactic, glycolic, and β-hydroxybutyric acids. Substances that are not metabolized by cells represent the other type. In the latter case, such products should not be toxic, and their concentration when entering the bloodstream should not exceed the established maximum permissible level. The composite materials based on a mixture of biodegradable synthetic and natural polymers with the addition of hydroxyapatite nanoparticles, which acts as a stabilizer of the dispersed system during production of the composite, and which is a biologically active component of the resulting matrix, were obtained and studied. The indirect effect of the shape, size, and surface charge of hydroxyapatite nanoparticles on the structure and porosity of the formed matrix was shown. An in vivo study showed the absence of acute toxicity of the developed composites. View Full-Text
Keywords: hydrophilic and hydrophobic polymers composites; hydroxyapatite nanoparticles; cell adhesion; cytotoxicity; acute toxicity hydrophilic and hydrophobic polymers composites; hydroxyapatite nanoparticles; cell adhesion; cytotoxicity; acute toxicity
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MDPI and ACS Style

Gordienko, M.; Karakatenko, E.; Menshutina, N.; Koroleva, M.; Gilmutdinova, I.; Eremin, P. Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties. J. Funct. Biomater. 2021, 12, 55. https://doi.org/10.3390/jfb12040055

AMA Style

Gordienko M, Karakatenko E, Menshutina N, Koroleva M, Gilmutdinova I, Eremin P. Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties. Journal of Functional Biomaterials. 2021; 12(4):55. https://doi.org/10.3390/jfb12040055

Chicago/Turabian Style

Gordienko, Mariia, Elena Karakatenko, Natalia Menshutina, Marina Koroleva, Ilmira Gilmutdinova, and Petr Eremin. 2021. "Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties" Journal of Functional Biomaterials 12, no. 4: 55. https://doi.org/10.3390/jfb12040055

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