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Open AccessArticle

Myristyltrimethylammonium Bromide (MYTAB) as a Cationic Surface Agent to Inhibit Streptococcus mutans Grown over Dental Resins: An In Vitro Study

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Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre-RS, Brazil
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Universidad Central del Ecuador, 170129 Quito, Ecuador
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Postgraduate Department, Universidad Regional Autónoma de Los Andes, 170129 Quito, Ecuador
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Oral Pathology Department, School of Dentistry, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre-RS, Brazil
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Operative Dentistry Division, General Dentistry Department, University of Maryland School of Dentistry, Baltimore, MD 21201, USA
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Ph.D. Program in Biomedical Sciences, University of Maryland School of Dentistry, Baltimore, MD 21201, USA
*
Authors to whom correspondence should be addressed.
J. Funct. Biomater. 2020, 11(1), 9; https://doi.org/10.3390/jfb11010009
Received: 16 January 2020 / Revised: 6 February 2020 / Accepted: 11 February 2020 / Published: 15 February 2020
(This article belongs to the Special Issue Bacterial Interactions with Dental and Medical Materials)
This in vitro study evaluated the effect of myristyltrimethylammonium bromide (MYTAB) on the physical, chemical, and biological properties of an experimental dental resin. The resin was formulated with dental dimetacrylate monomers and a photoinitiator/co-initiator system. MYTAB was added at 0.5 (G0.5%), 1 (G1%), and 2 (G2%) wt %, and one group remained without MYTAB and was used as the control (GCtrl). The resins were analyzed for the polymerization kinetics, degree of conversion, ultimate tensile strength (UTS), antibacterial activity against Streptococcus mutans, and cytotoxicity against human keratinocytes. Changes in the polymerization kinetics profiling were observed, and the degree of conversion ranged from 57.36% (±2.50%) for G2% to 61.88% (±1.91%) for G0.5%, without a statistically significant difference among groups (p > 0.05). The UTS values ranged from 32.85 (±6.08) MPa for G0.5% to 35.12 (±5.74) MPa for GCtrl (p > 0.05). MYTAB groups showed antibacterial activity against biofilm formation from 0.5 wt % (p < 0.05) and against planktonic bacteria from 1 wt % (p < 0.05). The higher the MYTAB concentration, the higher the cytotoxic effect, without differences between GCtrl e G0.5% (p > 0.05). In conclusion, the addition of 0.5 wt % of MYTAB did not alter the physical and chemical properties of the dental resin and provided antibacterial activity without cytotoxic effect. View Full-Text
Keywords: dental materials; dentistry; anti-bacterial agents; dental caries; biocompatible materials; biofilms; quaternary ammonium compounds dental materials; dentistry; anti-bacterial agents; dental caries; biocompatible materials; biofilms; quaternary ammonium compounds
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Mena Silva, P.A.; Garcia, I.M.; Nunes, J.; Visioli, F.; Castelo Branco Leitune, V.; Melo, M.A.; Collares, F.M. Myristyltrimethylammonium Bromide (MYTAB) as a Cationic Surface Agent to Inhibit Streptococcus mutans Grown over Dental Resins: An In Vitro Study. J. Funct. Biomater. 2020, 11, 9.

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