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Computation, Volume 12, Issue 5

May 2024 - 23 articles

Cover Story: In injured arteries, platelets adhere to the subendothelium, initiating coagulation and forming a plug to stop blood loss. To study this process, we enhance a previous multiscale model by incorporating intraplatelet calcium regulation. In this framework, platelets are modeled as soft spheres that can attach, detach, activate, or become non-adhesive. Extracellular agonists like ADP and thrombin, along with platelet contact, stimulate the calcium pathway, leading to activation. Simulations reveal a contact-dependent activation threshold for thrombus core formation. Blocking P2Y receptors reduces the number of platelets in the thrombus shell. The model predicts that platelet size heterogeneity decreases overall platelet recruitment and can study antiplatelet therapy efficacy under various conditions. View this paper
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Articles (23)

  • Article
  • Open Access
1,734 Views
9 Pages

Microbolometer arrays, i.e., arrays of micro-scale pixels sensing temperature via resistance changes, have proven to be an effective basis for real-time imaging instrumentation in infrared as well as terahertz frequencies. In previous work, a design...

  • Article
  • Open Access
3,988 Views
17 Pages

Modeling Density Waves and Circulations in Vertical Cross-Section in Adhesive Contacts

  • Aleksander E. Filippov,
  • Iakov A. Lyashenko and
  • Valentin L. Popov

This work continues the study of the process of friction between a steel spherical indenter and a soft elastic elastomer previously published in our paper. It is done in the context of our previous experimental results obtained on systems with strong...

  • Article
  • Open Access
2,185 Views
18 Pages

Accelerating Conjugate Heat Transfer Simulations in Squared Heated Cavities through Graphics Processing Unit (GPU) Computing

  • César Augusto Borges da Silva Reis,
  • Daniel Botezelli,
  • Arthur Mendonça de Azevedo,
  • Elisan dos Santos Magalhães and
  • Aristeu da Silveira Neto

This research develops an innovative framework for accelerating Conjugate Heat Transfer (CHT) simulations within squared heated cavities through the application of Graphics Processing Units (GPUs). Although leveraging GPUs for computational speed imp...

  • Article
  • Open Access
1 Citations
2,151 Views
22 Pages

Short Fiber-Reinforced Polymer Polyamide 6 Lugs and Selective Laser-Melted Ti-6Al-4V Bushing Contact Cohesive Zone Model Mode II Parameters’ Evaluation

  • Andry Sedelnikov,
  • Evgenii Kurkin,
  • Vitaliy Smelov,
  • Vladislava Chertykovtseva,
  • Vyacheslav Alekseev,
  • Andrey Gavrilov,
  • Evgenii Kishov,
  • Maksim Zvyagincev and
  • Sergey Chernyakin

This paper discusses an approach to estimating the parameters of the cohesive zone model (CZM) by mode II by extruding the bushing along the lug axis. This method of evaluation requires small samples, which is particularly relevant when investigating...

  • Article
  • Open Access
1 Citations
1,412 Views
33 Pages

Relation Models of Surface Parameters and Backscattering (or Radiation) Fields as a Tool for Solving Remote Sensing Problems

  • Kseniia Nezhalska,
  • Valerii Volosyuk,
  • Kostiantyn Bilousov,
  • Denys Kolesnikov and
  • Glib Cherepnin

In this paper, an analysis of existing models for describing surfaces of various types is performed, and the possibilities of their application at the level of mathematical modeling are analyzed. Moreover, due to the large number of models and the co...

  • Article
  • Open Access
3 Citations
1,535 Views
15 Pages

The paper is devoted to the comparative analysis of different CFD techniques used to solve the problem of high-pressure hydrogen release into the air. Three variations of a contemporary low-dissipation numerical technique (CABARET) are compared with...

  • Article
  • Open Access
1 Citations
1,911 Views
19 Pages

This paper presents the design and development of an electronic controller for accurate temperature management for the storage of biological and chemical samples in healthcare applications. In the introduction, some important application aspects rela...

  • Article
  • Open Access
6 Citations
3,322 Views
24 Pages

Unveiling AI-Generated Financial Text: A Computational Approach Using Natural Language Processing and Generative Artificial Intelligence

  • Muhammad Asad Arshed,
  • Ștefan Cristian Gherghina,
  • Christine Dewi,
  • Asma Iqbal and
  • Shahzad Mumtaz

This study is an in-depth exploration of the nascent field of Natural Language Processing (NLP) and generative Artificial Intelligence (AI), and it concentrates on the vital task of distinguishing between human-generated text and content that has bee...

  • Article
  • Open Access
2 Citations
1,753 Views
16 Pages

Quasi-interpolation is a powerful tool for approximating functions using radial basis functions (RBFs) such as Gaussian kernels. This avoids solving large systems of equations as in RBF interpolation. However, quasi-interpolation with Gaussian kernel...

  • Article
  • Open Access
2 Citations
2,757 Views
19 Pages

In injured arteries, platelets adhere to the subendothelium and initiate the coagulation process. They recruit other platelets and form a plug that stops blood leakage. The formation of the platelet plug depends on platelet activation, a process that...

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Computation - ISSN 2079-3197