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Mean Platelet Volume Predicts Vascular Access Events in Hemodialysis Patients

1
Centre de Néphrologie et Transplantation Rénale, Hôpital de la conception AP-HM, 13005 Marseille, France
2
Faculty of Pharmacy, Aix Marseille Univ, INSERM, INRA, C2VN, 13005 Marseille, France
3
Elsan, Phocean Institute of Nephrology, Clinique Bouchard, 13008 Marseille, France
4
Hematology and Vascular Biology Department, Hôpital de la Conception, AP-HM, 13005 Marseille, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(5), 608; https://doi.org/10.3390/jcm8050608
Received: 8 April 2019 / Revised: 25 April 2019 / Accepted: 2 May 2019 / Published: 4 May 2019
(This article belongs to the Section Nephrology & Urology)
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Abstract

Arteriovenous fistula (AVF) and arteriovenous graft (AVG) is the vascular access (VA) of 78% of hemodialysis patients (HD) in France. VA dysfunction corresponding to either stenosis requiring angioplasty or acute thrombosis is responsible for 30% of hospitalizations. Mean platelet volume (MPV) is a biological marker of cardiovascular events. We studied MPV in a cohort of HD patients as a predictive marker of VA dysfunction. We conducted a prospective monocentric cohort study that included patients with AVF or AVG on chronic HD (n = 153). The primary outcome was the incidence of VA dysfunction regarding MPV value. The median MPV was 10.8 fL (7.8–13.5), and four groups were designed according to MPV quartiles. Fifty-four patients experienced the first event of VA dysfunction. The incidence of VA dysfunction was higher in patients with the highest MPV: 59% (23 events), 34% (14 events), 27% (11 events), and 18% (6 events), respectively, for the fourth, third, second, and first quartiles (p = 0.001). Multivariate analysis confirmed an independent association between MPV and VA dysfunction—OR 1.52 (1.13–2.07), p < 0.001. VA dysfunction is predicted by MPV level. Patients with the highest MPV have the highest risk of VA events. View Full-Text
Keywords: arteriovenous fistula; hemodialysis; mean platelet volume; thrombosis; end-stage renal disease arteriovenous fistula; hemodialysis; mean platelet volume; thrombosis; end-stage renal disease
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Lano, G.; Sallée, M.; Pelletier, M.; Bataille, S.; Fraisse, M.; Berda-Haddad, Y.; Brunet, P.; Burtey, S. Mean Platelet Volume Predicts Vascular Access Events in Hemodialysis Patients. J. Clin. Med. 2019, 8, 608.

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