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Mean Platelet Volume Predicts Vascular Access Events in Hemodialysis Patients

Centre de Néphrologie et Transplantation Rénale, Hôpital de la conception AP-HM, 13005 Marseille, France
Faculty of Pharmacy, Aix Marseille Univ, INSERM, INRA, C2VN, 13005 Marseille, France
Elsan, Phocean Institute of Nephrology, Clinique Bouchard, 13008 Marseille, France
Hematology and Vascular Biology Department, Hôpital de la Conception, AP-HM, 13005 Marseille, France
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(5), 608;
Received: 8 April 2019 / Revised: 25 April 2019 / Accepted: 2 May 2019 / Published: 4 May 2019
(This article belongs to the Section Nephrology & Urology)
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Arteriovenous fistula (AVF) and arteriovenous graft (AVG) is the vascular access (VA) of 78% of hemodialysis patients (HD) in France. VA dysfunction corresponding to either stenosis requiring angioplasty or acute thrombosis is responsible for 30% of hospitalizations. Mean platelet volume (MPV) is a biological marker of cardiovascular events. We studied MPV in a cohort of HD patients as a predictive marker of VA dysfunction. We conducted a prospective monocentric cohort study that included patients with AVF or AVG on chronic HD (n = 153). The primary outcome was the incidence of VA dysfunction regarding MPV value. The median MPV was 10.8 fL (7.8–13.5), and four groups were designed according to MPV quartiles. Fifty-four patients experienced the first event of VA dysfunction. The incidence of VA dysfunction was higher in patients with the highest MPV: 59% (23 events), 34% (14 events), 27% (11 events), and 18% (6 events), respectively, for the fourth, third, second, and first quartiles (p = 0.001). Multivariate analysis confirmed an independent association between MPV and VA dysfunction—OR 1.52 (1.13–2.07), p < 0.001. VA dysfunction is predicted by MPV level. Patients with the highest MPV have the highest risk of VA events. View Full-Text
Keywords: arteriovenous fistula; hemodialysis; mean platelet volume; thrombosis; end-stage renal disease arteriovenous fistula; hemodialysis; mean platelet volume; thrombosis; end-stage renal disease

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Lano, G.; Sallée, M.; Pelletier, M.; Bataille, S.; Fraisse, M.; Berda-Haddad, Y.; Brunet, P.; Burtey, S. Mean Platelet Volume Predicts Vascular Access Events in Hemodialysis Patients. J. Clin. Med. 2019, 8, 608.

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