CA125 as a Marker of Heart Failure in the Older Women: A Population-Based Analysis
Abstract(1) Background: Cancer antigen 125 (CA125) is a glycoprotein that is expressed by tissue derived from coelomic epithelium in the pleura, peritoneum, pericardium. It has been shown that CA125 concentrations are correlated with NT-proBNP in older people with congestive heart failure (HF). We conducted a study on the association between concentrations of CA125 and NT-proBNP in a population-based cohort of older Polish women. (2) Methods: The current research is sub-study of a large, cross-sectional research project (PolSenior). The study group consisted of 1565 Caucasian women aged 65–102 years. To assess the relationship between CA125 and other variables a stepwise backward multivariate normal and skew-t regression analyses were performed. (3) Results: The median of CA125 concentration was 13.0 U/mL and values over the upper normal range limit (35 U/mL) were observed in 5.1% (n = 79) of the study cohort. The concentration of CA125 was positively related to age, hospitalization for HF and history of atrial fibrillation and chronic obstructive pulmonary disease, levels of NT-proBNP, IL-6, hs-CRP and triglycerides. We found in the multivariate analyses, that increased CA125 levels were independently associated with log10 (IL-6) (β = 11.022), history of hospitalization for HF (β = 4.619), log10 (NT-proBNP) (β = 4.416) and age (β = 3.93 for 10 years). (4) Conclusions: Despite the association between CA125 and NT-proBNP, the usefulness of CA125 for the detection of HF in older women is limited by factors such as inflammatory status and age. View Full-Text
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Bulska-Będkowska, W.; Chełmecka, E.; Owczarek, A.J.; Mizia-Stec, K.; Witek, A.; Szybalska, A.; Grodzicki, T.; Olszanecka-Glinianowicz, M.; Chudek, J. CA125 as a Marker of Heart Failure in the Older Women: A Population-Based Analysis. J. Clin. Med. 2019, 8, 607.
Bulska-Będkowska W, Chełmecka E, Owczarek AJ, Mizia-Stec K, Witek A, Szybalska A, Grodzicki T, Olszanecka-Glinianowicz M, Chudek J. CA125 as a Marker of Heart Failure in the Older Women: A Population-Based Analysis. Journal of Clinical Medicine. 2019; 8(5):607.Chicago/Turabian Style
Bulska-Będkowska, Weronika; Chełmecka, Elżbieta; Owczarek, Aleksander J.; Mizia-Stec, Katarzyna; Witek, Andrzej; Szybalska, Aleksandra; Grodzicki, Tomasz; Olszanecka-Glinianowicz, Magdalena; Chudek, Jerzy. 2019. "CA125 as a Marker of Heart Failure in the Older Women: A Population-Based Analysis." J. Clin. Med. 8, no. 5: 607.
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