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The Morphology, Structure, Mechanical Properties and Biocompatibility of Nanotubular Titania Coatings before and after Autoclaving Process
Open AccessArticle

“To Be Microbiocidal and Not to Be Cytotoxic at the Same Time…”—Silver Nanoparticles and Their Main Role on the Surface of Titanium Alloy Implants

1
Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland
2
Nano-implant Ltd., Gagarina 5/102, 87-100 Toruń, Poland
3
Faculty of Biology and Environmental Protection, Nicolaus Copernicus University in Toruń, Lwowska 1, 87-100 Toruń, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(3), 334; https://doi.org/10.3390/jcm8030334
Received: 10 February 2019 / Revised: 28 February 2019 / Accepted: 4 March 2019 / Published: 10 March 2019
(This article belongs to the Special Issue Biomaterial-Related Infections)
The chemical vapor deposition (CVD) method has been used to produce dispersed silver nanoparticles (AgNPs) on the surface of titanium alloy (Ti6Al4V) and nanotubular modified titanium alloys (Ti6Al4V/TNT5), leading to the formation of Ti6Al4V/AgNPs and Ti6Al4V/TNT5/AgNPs systems with different contents of metallic silver particles. Their surface morphology and silver particles arrangement were characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDS), and atomic force microscopy (AFM). The wettability and surface free energy of these materials were investigated on the basis of contact angle measurements. The degree of silver ion release from the surface of the studied systems immersed in phosphate buffered saline solution (PBS) was estimated using inductively coupled plasma ionization mass spectrometry (ICP-MS). The biocompatibility of the analyzed materials was estimated based on the fibroblasts and osteoblasts adhesion and proliferation, while their microbiocidal properties were determined against Gram-positive and Gram-negative bacteria, and yeasts. The results of our works proved the high antimicrobial activity and biocompatibility of all the studied systems. Among them, Ti6Al4V/TNT5/0.6AgNPs contained the lowest amount of AgNPs, but still revealed optimal biointegration properties and high biocidal properties. This is the biomaterial that possesses the desired biological properties, in which the potential toxicity is minimized by minimizing the number of silver nanoparticles. View Full-Text
Keywords: silver nanoparticles; titanium alloy; titanium dioxide nanotubes; silver ions release; biointegration; antimicrobial activity silver nanoparticles; titanium alloy; titanium dioxide nanotubes; silver ions release; biointegration; antimicrobial activity
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MDPI and ACS Style

Radtke, A.; Grodzicka, M.; Ehlert, M.; Jędrzejewski, T.; Wypij, M.; Golińska, P. “To Be Microbiocidal and Not to Be Cytotoxic at the Same Time…”—Silver Nanoparticles and Their Main Role on the Surface of Titanium Alloy Implants. J. Clin. Med. 2019, 8, 334.

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