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J. Clin. Med. 2019, 8(1), 81; https://doi.org/10.3390/jcm8010081

Sex-Differences in the Pattern of Comorbidities, Functional Independence, and Mortality in Elderly Inpatients: Evidence from the RePoSI Register

1
Department of Internal Medicine, National Relevance and High Specialization Hospital Trust ARNAS Civico, Di Cristina, Benfratelli, Palermo 90127, Italy
2
Materno Infantile, Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”, PROMISE, Dipartimento di Promozione della Salute, Università di Palermo, Palermo 90133, Italy
3
Department of Organizational, Clinical, and Translational Research, I.E.ME.S.T., Palermo 90139, Italy
4
Department of Neuroscience, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, Milan 20156, Italy
5
Department of Internal Medicine, University of Pavia and San Matteo Hospital, Pavia 27100, Italy
6
Scientific Direction, IRCCS Foundation Maggiore Policlinico Hospital, Milan 20122, Italy
7
Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy
*
Author to whom correspondence should be addressed.
Received: 10 December 2018 / Revised: 9 January 2019 / Accepted: 10 January 2019 / Published: 12 January 2019
(This article belongs to the Section Epidemiology & Public Health)
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Abstract

Background: The RePoSi study has provided data on comorbidities, polypharmacy, and sex dimorphism in hospitalised elderly patients. Methods: We retrospectively analysed data collected from the 2010, 2012, 2014, and 2016 data sets of the RePoSi register. The aim of this study was to explore the sex-differences and to validate the multivariate model in the entire dataset with an expanded follow-up at 1 year. Results: Among 4714 patients, 51% were women and 49% were men. The disease distribution showed that diabetes, coronary artery disease, chronic obstructive pulmonary disease, chronic kidney disease, and malignancy were more frequent in men but that hypertension, anaemia, osteoarthritis, depression, and diverticulitis disease were more common in women. Severity and comorbidity indexes according to the Cumulative Illness Rating Scale (CIRS-s and CIRS-c) were higher in men, while cognitive impairment, mood disorders, and disability in daily life measured by the Barthel Index (BI) were worse in women. In the multivariate analysis, BI, CIRS, and malignancy significantly increased the risk of death in men at the 1-year follow-up, while age was independently associated with mortality in women. Conclusions: Our study highlighted the relevance and the validity of our previous predictive model in the identification of sex dimorphism in hospitalised elderly patients underscoring the need of sex-personalised health-care. View Full-Text
Keywords: elderly; sex profiles; disease distribution; in-hospital mortality; 3-month mortality; 1-year mortality elderly; sex profiles; disease distribution; in-hospital mortality; 3-month mortality; 1-year mortality
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MDPI and ACS Style

Corrao, S.; Argano, C.; Natoli, G.; Nobili, A.; Corazza, G.R.; Mannucci, P.M.; Perticone, F.; on behalf of REPOSI Investigators. Sex-Differences in the Pattern of Comorbidities, Functional Independence, and Mortality in Elderly Inpatients: Evidence from the RePoSI Register. J. Clin. Med. 2019, 8, 81.

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