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Lipid Myopathies
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The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study

1
Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo, Km 2.2, 28220 Majadahonda, 28220 Madrid, Spain
2
Servicio de Digestivo, Hospital Virgen de la Salud, 45004 Toledo, Spain
3
Unidad de Gestión Clínica de Laboratorio, Hospital de Antequera, 29200 Málaga, Spain
*
Author to whom correspondence should be addressed.
These authors were equally contributed in this study.
J. Clin. Med. 2018, 7(12), 473; https://doi.org/10.3390/jcm7120473
Received: 19 October 2018 / Accepted: 21 November 2018 / Published: 23 November 2018
(This article belongs to the Section Molecular Diagnostics)
Background: The myeloid-epithelial-reproductive tyrosine kinase (MERTK) is involved in hepatic steatosis, inflammation, and liver fibrosis. Here we evaluated the association between the MERTK rs4374383 single nucleotide polymorphism (SNP) and liver fibrosis progression in hepatitis C virus (HCV)-infected patients. Methods: We performed a retrospective study (repeated measures design) in 208 patients who had liver stiffness measurement (LSM), which was assessed using transient elastography. No patient had cirrhosis at baseline (LSM ≥ 12.5 kPa). Results: At baseline, 53.8% were male, the median age was 47.1 years, 13.5% reported a high intake of alcohol, 10.1% were prior injection drug users, 85.3% were infected with HCV genotype 1, and 22.6% had previously failed antiviral therapy (pegylated-interferon-alpha/ribavirin). During a median follow-up of 46.6 months, 26 patients developed cirrhosis. The rs4374383 G carriers had a higher risk of increasing LSM (adjusted arithmetic mean ratio (aAMR) = 1.14; p = 0.006) and a higher likelihood of having an increase in LSM greater than 5 kPa (ΔLSM ≥ 5 kPa) (adjusted odds ratio (aOR) = 2.37; p = 0.029), and greater than 7 kPa (ΔLSM ≥ 7 kPa) (aOR = 3.24; p = 0.032), after controlling for confounding. The SNP’s association with cirrhosis progression was close to statistical significance (aOR = 2.18; p = 0.070). Conclusions: MERTK rs4374383 A carriers had a lower risk of liver fibrosis progression than G carriers, supporting the hypothesis that this SNP seems to have a critical role in the pathogenesis of liver disease in HCV-infected patients. View Full-Text
Keywords: liver stiffness; MERTK; chronic hepatitis C; cirrhosis; SNPs liver stiffness; MERTK; chronic hepatitis C; cirrhosis; SNPs
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MDPI and ACS Style

Jiménez-Sousa, M.Á.; Gómez-Moreno, A.Z.; Pineda-Tenor, D.; Brochado-Kith, O.; Sánchez-Ruano, J.J.; Artaza-Varasa, T.; Gómez-Sanz, A.; Fernández-Rodríguez, A.; Resino, S. The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study. J. Clin. Med. 2018, 7, 473. https://doi.org/10.3390/jcm7120473

AMA Style

Jiménez-Sousa MÁ, Gómez-Moreno AZ, Pineda-Tenor D, Brochado-Kith O, Sánchez-Ruano JJ, Artaza-Varasa T, Gómez-Sanz A, Fernández-Rodríguez A, Resino S. The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study. Journal of Clinical Medicine. 2018; 7(12):473. https://doi.org/10.3390/jcm7120473

Chicago/Turabian Style

Jiménez-Sousa, María Á.; Gómez-Moreno, Ana Z.; Pineda-Tenor, Daniel; Brochado-Kith, Oscar; Sánchez-Ruano, Juan J.; Artaza-Varasa, Tomas; Gómez-Sanz, Alicia; Fernández-Rodríguez, Amanda; Resino, Salvador. 2018. "The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study" J. Clin. Med. 7, no. 12: 473. https://doi.org/10.3390/jcm7120473

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