Next Article in Journal
Treatment of Acute Myeloid Leukemia in Adolescent and Young Adult Patients
Next Article in Special Issue
Polypoidal Choroidal Vasculopathy in Asians
Previous Article in Journal
Hypercalcemia Associated with Calcium Supplement Use: Prevalence and Characteristics in Hospitalized Patients
Previous Article in Special Issue
Age-Related Macular Degeneration: Advances in Management and Diagnosis
Open AccessArticle

Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study

1
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
2
Department of Biostatistics and Medical Informatics and Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
3
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
4
Department of Pathology and Laboratory Medicine, University of Kentucky College of Medicine, Lexington, KY 40536, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Lindsay Farrer and Margaret DeAngelis
J. Clin. Med. 2015, 4(3), 425-440; https://doi.org/10.3390/jcm4030425
Received: 15 January 2015 / Accepted: 24 February 2015 / Published: 9 March 2015
(This article belongs to the Special Issue Age-Related Macular Disease)
We tested the hypothesis that large areas of small hard drusen (diameter <63 µm) and intermediate drusen (diameter 63–124 µm) are associated with the incidence of age-related macular degeneration (AMD). Eyes of 3344 older adults with at least two consecutive visits spaced five years apart over a 20-year period were included. A 6-level severity scale, including no drusen, four levels of increasing area (from minimal (<2596 µm²) to large (>9086 µm²)) of only small hard drusen, and intermediate drusen, was used. The five-year incidence of AMD was 3% in eyes at the start of the interval with no, minimal, small, and moderate areas of only small drusen and 5% and 25% for eyes with large area of only small drusen and intermediate drusen, respectively. Compared to eyes with a moderate area of small drusen, the odds ratio (OR) of developing AMD in eyes with a large area of only small drusen was 1.8 (p < 0.001). Compared to eyes with large area of only small drusen, eyes with intermediate drusen had an OR of 5.5 (p < 0.001) of developing AMD. Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD. View Full-Text
Keywords: age-related macular degeneration; epidemiology; genetic risk; incidence; retinal drusen; risk factors; size and area age-related macular degeneration; epidemiology; genetic risk; incidence; retinal drusen; risk factors; size and area
Show Figures

Figure 1

MDPI and ACS Style

Klein, R.; Myers, C.E.; Lee, K.E.; Gangnon, R.E.; Sivakumaran, T.A.; Iyengar, S.K.; Klein, B.E.K. Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study. J. Clin. Med. 2015, 4, 425-440. https://doi.org/10.3390/jcm4030425

AMA Style

Klein R, Myers CE, Lee KE, Gangnon RE, Sivakumaran TA, Iyengar SK, Klein BEK. Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study. Journal of Clinical Medicine. 2015; 4(3):425-440. https://doi.org/10.3390/jcm4030425

Chicago/Turabian Style

Klein, Ronald; Myers, Chelsea E.; Lee, Kristine E.; Gangnon, Ronald E.; Sivakumaran, Theru A.; Iyengar, Sudha K.; Klein, Barbara E.K. 2015. "Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study" J. Clin. Med. 4, no. 3: 425-440. https://doi.org/10.3390/jcm4030425

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop