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Treatment of Acute Myeloid Leukemia in Adolescent and Young Adult Patients

Department of Hematology, Ankara University School of Medicine, Ankara 06100, Turkey
Author to whom correspondence should be addressed.
Academic Editor: Celalettin Ustun
J. Clin. Med. 2015, 4(3), 441-459;
Received: 5 September 2014 / Accepted: 3 February 2015 / Published: 11 March 2015
(This article belongs to the Special Issue AML in the Molecular Age: From Biology to Clinical Management)
PDF [154 KB, uploaded 11 March 2015]


The objectives of this review were to discuss standard and investigational treatment strategies for adolescent and young adult with acute myeloid leukemia, excluding acute promyelocytic leukemia. Acute myeloid leukemia (AML) in adolescent and young adult patients (AYAs) may need a different type of therapy than those currently used in children and older patients. As soon as AML is diagnosed, AYA patient should be offered to participate in well-designed clinical trials. The standard treatment approach for AYAs with AML is remission induction chemotherapy with an anthracycline/cytarabine combination, followed by either consolidation chemotherapy or stem cell transplantation, depending on the ability of the patient to tolerate intensive treatment and cytogenetic features. Presently, continuing progress of novel drugs targeting specific pathways in acute leukemia may bring AML treatment into a new era. View Full-Text
Keywords: acute myeloid leukemia; adolescent and young adults; treatment acute myeloid leukemia; adolescent and young adults; treatment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Seval, G.C.; Ozcan, M. Treatment of Acute Myeloid Leukemia in Adolescent and Young Adult Patients. J. Clin. Med. 2015, 4, 441-459.

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