Accumulated Vitrified Embryos Could Be a Method for Increasing Pregnancy Rates in Patients with Poor Ovarian Response
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Patients
2.2. COS Protocol and Fresh ET
2.3. Accumulation of Vitrified Embryos and Thawing Procedure
2.4. ACC-ET (Frozen Thawed ET)
2.5. ACC-ET (Combined Fresh and Frozen Thawed ET)
2.6. Outcome Measure
3. Results
3.1. ACC-ET vs. Fresh ET
3.2. Subgroup Analysis
3.2.1. Frozen Thawed ACC-ET vs. Fresh ET
3.2.2. Frozen Thawed + Fresh ACC-ET and Fresh ET
3.2.3. Fresh ET
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Fresh ET (n = 517) | ACC-ET (n = 71) | p-Value | ACC-ET | ||||
---|---|---|---|---|---|---|---|
Frozen | Frozen + Fresh | ||||||
Frozen (n = 47) | p-Value (Compared to Fresh ET) | Frozen + Fresh (n = 24) | p-Value (Compared to Fresh ET) | ||||
Age (years) | 38.2 ± 3.7 | 38.1 ± 3.5 | 0.88 | 37.7 ± 3.2 | 0.42 | 38.9 ± 4.1 | 0.38 |
BMI (kg/m2) | 21.8 ± 3.3 | 21.6 ± 2.2 | 0.49 | 21.5 ± 2.2 | 0.54 | 21.8 ± 2.0 | 0.99 |
AMH (ng/mL) (±SD) | 0.6 ± 0.6 | 0.5 ± 0.4 | 0.38 | 0.5 ± 0.4 | 0.52 | 0.5 ± 0.3 | 0.52 |
Duration of infertility (years) | 5.2 ± 3.8 | 5.6 ± 4.2 | 0.42 | 4.9 ± 4.0 | 0.61 | 6.9 ± 4.4 | 0.03 |
FSH (mIU/mL) (±SD) | 10.8 ± 9.0 | 11.9 ± 8.0 | 0.35 | 10.6 ± 7.5 | 0.91 | 14.4 ± 8.6 | 0.06 |
Previous IVF-ET cycles (±SD) | 2.8 ± 2.4 | 2.6 ± 3.1 | 0.72 | 2.2 ± 2.9 | 0.13 | 3.5 ± 3.3 | 0.31 |
Fresh ET (n = 517) | ACC-ET (n = 71) | p Value | ACC-ET | ||||
---|---|---|---|---|---|---|---|
Frozen | Fresh + Frozen | ||||||
N = 47 | #p Value (Compared to Fresh ET) | N = 24 | #p Value (Compared to Fresh ET) | ||||
No retrieved oocyte/ET | 2.1 ± 0.8 | 4.9 ± 2.6 | 0.00 | 5.5 ± 2.8 | 0.00 | 3.5 ± 1.1 | 0.00 |
No retrieved oocyte/retrieval | 2.1 ± 0.8 | 1.6 ± 0.9 | 0.00 | 1.8 ± 1.0 | 0.025 | 1.25 ± 0.6 | 0.00 |
1.8 ± 1.0 | 1.25 ± 0.6 | 0.009 ## | |||||
Average number of OPU attempts | 3.3 (239/71) | 3.4 (160/47) | 3.29 (79/24) | ||||
Maturation rate | 61.1 ± 36.5 | 57.6 ± 28.9 | 0.35 | 63.4 ± 27.9 | 0.59 | 46.1 ± 27.8 | 0.017 |
Fertilization rate (%) (±SD) | 87.6 ± 28.3 | 78.4 ± 22.6 | 0.009 | 73.4 ± 24.2 | 0.00 | 88.2 ± 15.3 | 0.90 |
No. of transferred embryo | 1.5 ± 0.7 | 3.1 ± 0.9 | 0.00 | 3.3 ± 1.0 | 0.00 | 2.8 ± 0.7 | 0.00 |
Good quality embryo (%) | 65.4 ± 41.0 | 48.2 ± 30.5 | 0.00 | 43.8 ± 30.0 | 0.00 | 56.5 ± 29.9 | 0.17 |
Cancellation rate | 18.8 (45/239) | 16.8 (27/160) | 22.7 (18/79) | ||||
Survival rate of Thawed embryo | - | - | - | 97.1 (169/174) | - | 100 (41/41) | - |
Pregnancy rate | 18.8 (97/517) | 29.6 (21/71) | 0.040 | 29.8 (14.47) | 0.119 | 29.2 (7/24) | 0.291 |
Clinical pregnancy rate | 14.0 (71/508) | 23.5 (16/68) | 0.047 | 22.7 (10/44) | 0.189 | 25.0 (6/24) | 0.240 |
Live birth rate | 9.8 (50/508) | 14.9 (10/67) | 0.203 | 16.3 (7/43) | 0.277 | 12.5 (3/24) | 0.708 |
Fresh | p-Value | |||
---|---|---|---|---|
No. of ET | 1 | 2 | 3 | |
Pregnancy rate | 13.5 (35/259) | 22.8 (43/189) | 33.9 (19/56) | 0.00 |
Clinical pregnancy rate | 9.8 (25/255) | 16.7 (31/186) | 27.8 (15/54) | 0.001 |
Live birth rate | 6.7 (17/255) | 11.3 (21/186) | 22.2 (12/54) | 0.003 |
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Shin, J.; Kwon, H.; Choi, D.H.; Park, C.; Kim, J.H.; Kim, J.; Kang, Y.-J.; Koo, H.S. Accumulated Vitrified Embryos Could Be a Method for Increasing Pregnancy Rates in Patients with Poor Ovarian Response. J. Clin. Med. 2022, 11, 4940. https://doi.org/10.3390/jcm11174940
Shin J, Kwon H, Choi DH, Park C, Kim JH, Kim J, Kang Y-J, Koo HS. Accumulated Vitrified Embryos Could Be a Method for Increasing Pregnancy Rates in Patients with Poor Ovarian Response. Journal of Clinical Medicine. 2022; 11(17):4940. https://doi.org/10.3390/jcm11174940
Chicago/Turabian StyleShin, Jieun, Hwang Kwon, Dong Hee Choi, Chan Park, Ji Hyang Kim, Jeehyun Kim, Youn-Jung Kang, and Hwa Seon Koo. 2022. "Accumulated Vitrified Embryos Could Be a Method for Increasing Pregnancy Rates in Patients with Poor Ovarian Response" Journal of Clinical Medicine 11, no. 17: 4940. https://doi.org/10.3390/jcm11174940
APA StyleShin, J., Kwon, H., Choi, D. H., Park, C., Kim, J. H., Kim, J., Kang, Y.-J., & Koo, H. S. (2022). Accumulated Vitrified Embryos Could Be a Method for Increasing Pregnancy Rates in Patients with Poor Ovarian Response. Journal of Clinical Medicine, 11(17), 4940. https://doi.org/10.3390/jcm11174940