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Volume 13
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10.3390/vaccines13030319
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Article

Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis

by
Demian Bellido
1,2,*,
Diego Wenz
1,
Martin Schang
1,
Facundo Tibaldo Rubiolo
1,
Pablo Mangioni
1,
Emanuel Gumina
1,
Andrés Wigdorovitz
2,3 and
Viviana Parreño
3,*
1
Vetanco SA, Villa Martelli, Buenos Aires, CP 1603, Argentina
2
Bioinnovo SA, Villa Martelli, Buenos Aires, CP1603, Argentina
3
Incuinta, IVIT INTA, Hurlingham, Buenos Aires, CP1686, Argentina
*
Authors to whom correspondence should be addressed.
Vaccines 2025, 13(3), 319; https://doi.org/10.3390/vaccines13030319
Submission received: 29 November 2024 / Revised: 28 February 2025 / Accepted: 11 March 2025 / Published: 17 March 2025
(This article belongs to the Section Veterinary Vaccines)
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Abstract

Objective: This study evaluated the effect of a novel subunit-targeted vaccine against BVDV in six dairy farms in Argentina. Methods: Reproductive, health, and production parameters—including conception and abortion rates, open days, calves born per insemination, as well as newborn and overall mortality, and milk production—were monitored over a ten-year period (2014–2023). Data were analyzed annually to assess trends and compare the periods before and after vaccine introduction. Results: All parameters showed significant improvement after vaccine incorporation, with an 11% increase in conception rate, a 5% reduction in abortion rate, a 12% increase in calves per insemination rate, and a decrease of 11 open days (8.4%). Additionally, newborn mortality and overall mortality decreased by 33% and 16%, respectively, while milk production increased by 9%. These data were also compared with eight non-vaccinated dairy farms, and significant differences were observed in health and reproductive parameters. Conclusions: These findings indicate that vaccination with an effective non-replicating subunit vaccine can successfully minimize the impact of BVDV in dairy farms.
Keywords: bovine viral diarrhea virus; targeted vaccine; dairy farm bovine viral diarrhea virus; targeted vaccine; dairy farm

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MDPI and ACS Style

Bellido, D.; Wenz, D.; Schang, M.; Tibaldo Rubiolo, F.; Mangioni, P.; Gumina, E.; Wigdorovitz, A.; Parreño, V. Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis. Vaccines 2025, 13, 319. https://doi.org/10.3390/vaccines13030319

AMA Style

Bellido D, Wenz D, Schang M, Tibaldo Rubiolo F, Mangioni P, Gumina E, Wigdorovitz A, Parreño V. Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis. Vaccines. 2025; 13(3):319. https://doi.org/10.3390/vaccines13030319

Chicago/Turabian Style

Bellido, Demian, Diego Wenz, Martin Schang, Facundo Tibaldo Rubiolo, Pablo Mangioni, Emanuel Gumina, Andrés Wigdorovitz, and Viviana Parreño. 2025. "Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis" Vaccines 13, no. 3: 319. https://doi.org/10.3390/vaccines13030319

APA Style

Bellido, D., Wenz, D., Schang, M., Tibaldo Rubiolo, F., Mangioni, P., Gumina, E., Wigdorovitz, A., & Parreño, V. (2025). Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis. Vaccines, 13(3), 319. https://doi.org/10.3390/vaccines13030319

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