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Antioxidants and Skin Protection
 
 
Article

The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities

1
Department of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province, Jeju 63243, Korea
2
Marine Science Institute, Jeju National University, Jeju Self-Governing Province, Jeju 63243, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Antioxidants 2020, 9(8), 724; https://doi.org/10.3390/antiox9080724
Received: 8 July 2020 / Revised: 1 August 2020 / Accepted: 6 August 2020 / Published: 9 August 2020
(This article belongs to the Special Issue Antioxidants and Skin Protection II)
Sulfated polysaccharides prepared from marine algae are potential ingredients in nutraceutical, pharmaceutical, and cosmeceutical industries. In the present study, the antioxidant, anti-melanogenesis, and photoprotective effects of sulfated polysaccharides obtained from Ecklonia maxima (EMC) were investigated to evaluate their potential in cosmetic. EMC was successfully prepared through Celluclast-assisted extraction and ethanol precipitation, and it contained 79.88% of sulfated polysaccharides that with 69.37% carbohydrates and 10.51% sulfate. EMC effectively suppressed 2,2-azobis(2-amidinopropane) hydrochloride (AAPH)-induced oxidative stress in vitro in Vero cells and in vivo in zebrafish. Furthermore, EMC significantly inhibited mushroom tyrosinase and reduced melanin synthesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells. In addition, EMC remarkably attenuated photodamage induced by UVB irradiation in vitro in human keratinocytes (HaCaT cells) and in vivo in zebrafish. Furthermore, EMC effectively inhibited wrinkle-related enzymes and improved collagen synthesis in UVB-irradiated human dermal fibroblasts (HDF cells). These results indicate that EMC possesses strong antioxidant, anti-melanogenesis, and photoprotective activities, and suggest that EMC may be an ideal ingredient in the pharmaceutical and cosmeceutical industries. View Full-Text
Keywords: Ecklonia maxima; sulfated polysaccharides; oxidative stress; melanogenesis; UVB irradiation Ecklonia maxima; sulfated polysaccharides; oxidative stress; melanogenesis; UVB irradiation
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MDPI and ACS Style

Wang, L.; Jayawardena, T.U.; Yang, H.-W.; Lee, H.-G.; Jeon, Y.-J. The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities. Antioxidants 2020, 9, 724. https://doi.org/10.3390/antiox9080724

AMA Style

Wang L, Jayawardena TU, Yang H-W, Lee H-G, Jeon Y-J. The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities. Antioxidants. 2020; 9(8):724. https://doi.org/10.3390/antiox9080724

Chicago/Turabian Style

Wang, Lei, Thilina U. Jayawardena, Hye-Won Yang, Hyo-Geun Lee, and You-Jin Jeon. 2020. "The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities" Antioxidants 9, no. 8: 724. https://doi.org/10.3390/antiox9080724

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