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Open AccessArticle

Outcomes Assessment of Sustainable and Innovatively Simple Lifestyle Modification at the Workplace-Drinking Electrolyzed-Reduced Water (OASIS-ERW): A Randomized, Double-Blind, Placebo-Controlled Trial

1
Department of Family Medicine, Bundang Jesaeng General Hospital, Seongnam-si, Gyeonggi-do 13590, Korea
2
Department of Physiology, School of Medicine, CHA University, Seongnam-si, Gyeonggi-do 13488, Korea
3
Department of Clinical Pharmacology, School of Medicine, CHA University, Seongnam-si, Gyeonggi-do 13496, Korea
4
Department of Family Medicine, Yonsei University College of Medicine, Seoul 06273, Korea
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this study.
Antioxidants 2020, 9(7), 564; https://doi.org/10.3390/antiox9070564 (registering DOI)
Received: 27 April 2020 / Revised: 30 May 2020 / Accepted: 30 May 2020 / Published: 27 June 2020
Oxidative stress has been associated with many diseases as well as aging. Electrolyzed-reduced water (ERW) has been suggested to reduce oxidative stress and improve antioxidant potential. This study investigated the effects of drinking ERW on biomarkers of oxidative stress and health-related indices in healthy adults. We conducted a randomized, double-blind, placebo-controlled clinical trial on 65 participants, who were allocated into two groups. Of these, 61 received intervention (32 with ERW and 29 MW [mineral water]). All participants were instructed to drink 1.5 L/day of ERW or MW for eight weeks. Biomarkers of oxidative stress and health-related indices were assessed at baseline as well as after 4 weeks and 8 weeks of intervention. Of the primary outcome variables assessed, diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential showed a significant interaction between the groups and time, with d-ROMs levels significantly decreased at 8 weeks in ERW compared to those in MW. Among the secondary outcome variables, total, visceral, and subcutaneous fat mass significantly changed over time, with a significant association observed between the group and time. Thus, daily ERW consumption may be a potential consideration for a sustainable and innovatively simple lifestyle modification at the workplace to reduce oxidative stress, increase antioxidant potential, and decrease fat mass. View Full-Text
Keywords: oxidative stress; electrolyzed-reduced water; biomarkers of oxidative stress; reactive oxygen metabolites; biological antioxidant potential; fat mass; lifestyle modification oxidative stress; electrolyzed-reduced water; biomarkers of oxidative stress; reactive oxygen metabolites; biological antioxidant potential; fat mass; lifestyle modification
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Choi, Y.A.; Lee, D.H.; Cho, D.-Y.; Lee, Y.-J. Outcomes Assessment of Sustainable and Innovatively Simple Lifestyle Modification at the Workplace-Drinking Electrolyzed-Reduced Water (OASIS-ERW): A Randomized, Double-Blind, Placebo-Controlled Trial. Antioxidants 2020, 9, 564.

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