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Article

Bariatric Surgery Normalizes Protein Glycoxidation and Nitrosative Stress in Morbidly Obese Patients

1
Department of General and Endocrine Surgery, Medical University of Bialystok, 24a M. Sklodowskiej-Curie Street, 15-276 Bialystok, Poland
2
Department of Dermatology and Venereology, Medical University of Bialystok, 14 Żurawia Street, 15-540 Bialystok, Poland
3
Department of Oral Surgery, Medical University of Gdansk, 7 Dębinki Street, 80-211 Gdansk, Poland
4
Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, 2c Mickiewicza Street, 15-233 Bialystok, Poland
5
Experimental Dentistry Laboratory, Medical University of Bialystok, 24a M. Sklodowskiej-Curie Street, 15-274 Bialystok, Poland
*
Authors to whom correspondence should be addressed.
Antioxidants 2020, 9(11), 1087; https://doi.org/10.3390/antiox9111087
Received: 27 September 2020 / Revised: 2 November 2020 / Accepted: 2 November 2020 / Published: 4 November 2020
(This article belongs to the Special Issue Oxidative-Nitrative Stress in Human Health and Disease)
The results of recent studies indicate the key role of nitrosative stress and protein oxidative damage in the development of morbid obesity. Nevertheless, the effect of bariatric surgery on protein oxidation/glycation and nitrosative/nitrative stress is not yet known. This is the first study evaluating protein glycoxidation and protein nitrosative damage in morbidly obese patients before and after (one, three, six and twelve months) laparoscopic sleeve gastrectomy. The study included 50 women with morbid obesity as well as 50 age- and gender-matched healthy controls. We demonstrated significant increases in serum myeloperoxidase, plasma glycooxidative products (dityrosine, kynurenine, N-formyl-kynurenine, amyloid, Amadori products, glycophore), protein oxidative damage (ischemia modified albumin) and nitrosative/nitrative stress (nitric oxide, peroxy-nitrite, S-nitrosothiols and nitro-tyrosine) in morbidly obese subjects as compared to lean controls, whereas plasma tryptophan and total thiols were statistically decreased. Bariatric surgery generally reduces the abnormalities in the glycoxidation of proteins and nitrosative/nitrative stress. Noteworthily, in the patients with metabolic syndrome (MS+), we showed no differences in most redox biomarkers, as compared to morbidly obese patients without MS (MS−). However, two markers: were able to differentiate MS+ and MS− with high specificity and sensitivity: peroxy-nitrite (>70%) and S-nitrosothiols (>60%). Further studies are required to confirm the diagnostic usefulness of such biomarkers. View Full-Text
Keywords: morbid obesity; bariatric surgery; protein glycoxidation; nitrosative stress morbid obesity; bariatric surgery; protein glycoxidation; nitrosative stress
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MDPI and ACS Style

Choromańska, B.; Myśliwiec, P.; Łuba, M.; Wojskowicz, P.; Myśliwiec, H.; Choromańska, K.; Dadan, J.; Żendzian-Piotrowska, M.; Zalewska, A.; Maciejczyk, M. Bariatric Surgery Normalizes Protein Glycoxidation and Nitrosative Stress in Morbidly Obese Patients. Antioxidants 2020, 9, 1087. https://doi.org/10.3390/antiox9111087

AMA Style

Choromańska B, Myśliwiec P, Łuba M, Wojskowicz P, Myśliwiec H, Choromańska K, Dadan J, Żendzian-Piotrowska M, Zalewska A, Maciejczyk M. Bariatric Surgery Normalizes Protein Glycoxidation and Nitrosative Stress in Morbidly Obese Patients. Antioxidants. 2020; 9(11):1087. https://doi.org/10.3390/antiox9111087

Chicago/Turabian Style

Choromańska, Barbara, Piotr Myśliwiec, Magdalena Łuba, Piotr Wojskowicz, Hanna Myśliwiec, Katarzyna Choromańska, Jacek Dadan, Małgorzata Żendzian-Piotrowska, Anna Zalewska, and Mateusz Maciejczyk. 2020. "Bariatric Surgery Normalizes Protein Glycoxidation and Nitrosative Stress in Morbidly Obese Patients" Antioxidants 9, no. 11: 1087. https://doi.org/10.3390/antiox9111087

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