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Open AccessArticle

Gallic Acid-Dextran Conjugate: Green Synthesis of a Novel Antioxidant Molecule

Department of Biochemistry, Universidade Federal do Rio Grande do Norte, Natal 59.078-970, Rio Grande do Norte, Brazil
Department of Biochemistry and Molecular Biology, Universidade Federal do Paraná, Curitiba, Paraná 81.531-980, Brazil
Department of Biology, Instituto Federal de Educação, Ciência, e Tecnologia do Rio Grande do Norte (IFRN), Rio Grande do Norte, Canguaretama 59.500-000, Rio Grande do Norte, Brazil
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(10), 478;
Received: 5 July 2019 / Revised: 27 July 2019 / Accepted: 29 July 2019 / Published: 12 October 2019
A novel derivative of dextran, dextran–gallic acid (Dex–Gal), obtained from simple conjugation with gallic acid, was synthesized by an efficient free radical-mediated method. To verify the synthesis of Dex–Gal, 1H-nuclear magnetic resonance (1H-NMR), Fourier transform infrared (FTIR) spectrometry, and high-performance size-exclusion chromatography (HPSEC) were employed. The results revealed the conjugation of gallic acid with the 15.5 kDa dextran from Leuconostoc mesenteroides. Dex–Gal had a molecular weight of 11.2 kDa, indicating that the conjugation reaction was accompanied by a minor degradation of Dex–Gal. In addition, Dex–Gal contained 36.8 ± 1.4 mg gallic acid per gram dextran. These molecules were also evaluated as antioxidants using total antioxidant capacity (TAC), reducing power, ferric chelation, and superoxide radical-scavenging assays. Both polysaccharides had no ferric chelation activity. In addition, Dex–Gal was more efficient as an antioxidant agent in TAC (13 times) and was more efficient than dextran in superoxide radical-scavenging (60 times) and reducing power (90 times) assays. These data demonstrate that Dex–Gal is a natural-compound-based antioxidant with potential applications in the pharmaceutical, cosmetic, and food industries. View Full-Text
Keywords: gallic acid-grafted dextran; Leuconostoc dextran; antioxidant polysaccharide gallic acid-grafted dextran; Leuconostoc dextran; antioxidant polysaccharide
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Queiroz, M.F.; Sabry, D.A.; Sassaki, G.L.; Rocha, H.A.O.; Costa, L.S. Gallic Acid-Dextran Conjugate: Green Synthesis of a Novel Antioxidant Molecule. Antioxidants 2019, 8, 478.

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