Next Article in Journal
Quercetin Can Alleviate ETECK88-Induced Oxidative Stress in Weaned Piglets by Inhibiting Quorum-Sensing Signal Molecule Autoinducer-2 Production in the Cecum
Previous Article in Journal
Early-Life Prevention of Cardiovascular–Kidney–Metabolic Syndrome: The DOHaD Perspective on Resveratrol and Short-Chain Fatty Acids
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Antioxidants
Volume 14
Issue 7
10.3390/antiox14070853
antioxidants-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

The Mechanism of Protective Action of Plant-Derived Squalane (2,6,10,15,19,23-Hexamethyltetracosane) Against UVA Radiation-Induced Apoptosis in Human Dermal Fibroblasts

by
Katarzyna Wolosik
1,
Magda Chalecka
2,
Gabriela Gasiewska
2,
Jerzy Palka
2 and
Arkadiusz Surazynski
2,*
1
Independent Cosmetology Laboratory, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland
2
Department of Medicinal Chemistry, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Antioxidants 2025, 14(7), 853; https://doi.org/10.3390/antiox14070853
Submission received: 4 June 2025 / Revised: 1 July 2025 / Accepted: 9 July 2025 / Published: 11 July 2025
(This article belongs to the Special Issue Antioxidant Phytochemicals for Promoting Human Health and Well-Being)
Versions Notes

Abstract

Ultraviolet A (UVA) radiation has been identified as a significant factor contributing to skin photoaging and skin diseases, operating through the excessive generation of reactive oxygen species (ROS) and the subsequent induction of DNA damage. Plant-derived antioxidants have demonstrated efficacy in mitigating UVA-induced damage; nevertheless, their instability limits their therapeutic potential. This study investigates the mechanisms of antioxidant and cytoprotective effects of squalane (Sq), a stable, plant-derived triterpene, in human dermal fibroblasts (HDFs) exposed to UVA radiation. Sq was administered at concentrations ranging from 0.005% to 0.015% prior to UVA exposure (10 J/cm2). It has been found that Sq counteracted UVA-induced ROS formation, decreased the level of reduced thiol groups, activated apoptosis, and inhibited DNA biosynthesis. Immunofluorescence analysis revealed that Sq suppressed the UVA-induced expression of p53, caspase-3, caspase-9, and PARP, while restoring the activity of the pro-survival p-Akt/mTOR pathway. The findings indicate that Sq exerts protective effects on UVA-induced fibroblast damage through a combination of antioxidant and anti-apoptotic mechanisms.
Keywords: squalane; UVA radiation; oxidative stress; DNA damage; ROS; apoptosis squalane; UVA radiation; oxidative stress; DNA damage; ROS; apoptosis

Share and Cite

MDPI and ACS Style

Wolosik, K.; Chalecka, M.; Gasiewska, G.; Palka, J.; Surazynski, A. The Mechanism of Protective Action of Plant-Derived Squalane (2,6,10,15,19,23-Hexamethyltetracosane) Against UVA Radiation-Induced Apoptosis in Human Dermal Fibroblasts. Antioxidants 2025, 14, 853. https://doi.org/10.3390/antiox14070853

AMA Style

Wolosik K, Chalecka M, Gasiewska G, Palka J, Surazynski A. The Mechanism of Protective Action of Plant-Derived Squalane (2,6,10,15,19,23-Hexamethyltetracosane) Against UVA Radiation-Induced Apoptosis in Human Dermal Fibroblasts. Antioxidants. 2025; 14(7):853. https://doi.org/10.3390/antiox14070853

Chicago/Turabian Style

Wolosik, Katarzyna, Magda Chalecka, Gabriela Gasiewska, Jerzy Palka, and Arkadiusz Surazynski. 2025. "The Mechanism of Protective Action of Plant-Derived Squalane (2,6,10,15,19,23-Hexamethyltetracosane) Against UVA Radiation-Induced Apoptosis in Human Dermal Fibroblasts" Antioxidants 14, no. 7: 853. https://doi.org/10.3390/antiox14070853

APA Style

Wolosik, K., Chalecka, M., Gasiewska, G., Palka, J., & Surazynski, A. (2025). The Mechanism of Protective Action of Plant-Derived Squalane (2,6,10,15,19,23-Hexamethyltetracosane) Against UVA Radiation-Induced Apoptosis in Human Dermal Fibroblasts. Antioxidants, 14(7), 853. https://doi.org/10.3390/antiox14070853

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop