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Article

Dietary Zinc Is Associated with Cardiac Function in the Older Adult Population

1
Department of Sports Medicine, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland
2
Department of Geriatrics, Healthy Ageing Research Centre, Medical University of Lodz, Plac Hallera 1, 90-647 Lodz, Poland
3
Department of Laboratory Diagnostics and Clinical Biochemistry, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland
*
Author to whom correspondence should be addressed.
Antioxidants 2023, 12(2), 265; https://doi.org/10.3390/antiox12020265
Received: 30 December 2022 / Revised: 20 January 2023 / Accepted: 20 January 2023 / Published: 24 January 2023
(This article belongs to the Special Issue Dietary Antioxidants and Cardiovascular Health)

Abstract

The elderly is a group at particularly high cardiovascular risk. The coexistence of chronic diseases and use of multiple medications creates the need to look for non-pharmacological agents to improve cardiovascular health in that population. In view of reports on the potential role of zinc in enhancing pathways of myocardial tissue repair, the aim of this study was to evaluate the association between dietary zinc intake and cardiac structure and function in individuals of advanced age. The study group included 251 community-dwelling patients, with a median age of 80 years. Dieta 6.0 software was used for calculation of zinc consumption. Percentage of Recommended Dietary Allowance (RDA) for zinc correlated with left ventricular ejection fraction (LVEF) (r = 0.196, p < 0.05), left ventricular mass index (r = −0.137, p < 0.05) and tricuspid annular plane systolic excursion (TAPSE) (r = 0.153, p < 0.05), while zinc density did so with E/E’ ratio (r = −0.127, p < 0.05). In a multiple stepwise regression analysis, the best determinants of LVEF were %RDA for zinc (p = 0.014; β = 0.143), presence of coronary artery disease (p < 0.001; β = −0.39) and age (p = 0.036; β = −0.12). Furthermore, %RDA for zinc (p = 0.009; β = 0.16), female sex (p = 0.005; β = −0.171), beta-blocker use (p = 0.024; β = −0.136), body mass index (p = 0.008; β = 0.16) and heart rate (p = 0.0006; β = −0.209) had an independent effect on TAPSE. In conclusion, in individuals of very advanced age, lower zinc intake is associated with poorer cardiac function. Therefore, increasing the recommended zinc intake in this group deserves consideration.
Keywords: dietary antioxidants; dietary zinc intake; cardiovascular health; aging; echocardiography; ejection fraction dietary antioxidants; dietary zinc intake; cardiovascular health; aging; echocardiography; ejection fraction

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MDPI and ACS Style

Szadkowska, I.; Kostka, T.; Wlazeł, R.N.; Kroc, Ł.; Jegier, A.; Guligowska, A. Dietary Zinc Is Associated with Cardiac Function in the Older Adult Population. Antioxidants 2023, 12, 265. https://doi.org/10.3390/antiox12020265

AMA Style

Szadkowska I, Kostka T, Wlazeł RN, Kroc Ł, Jegier A, Guligowska A. Dietary Zinc Is Associated with Cardiac Function in the Older Adult Population. Antioxidants. 2023; 12(2):265. https://doi.org/10.3390/antiox12020265

Chicago/Turabian Style

Szadkowska, Iwona, Tomasz Kostka, Rafał Nikodem Wlazeł, Łukasz Kroc, Anna Jegier, and Agnieszka Guligowska. 2023. "Dietary Zinc Is Associated with Cardiac Function in the Older Adult Population" Antioxidants 12, no. 2: 265. https://doi.org/10.3390/antiox12020265

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