The Beneficial Effects of Heme Oxygenase 1 and Hydrogen Sulfide Activation in the Management of Neuropathic Pain, Anxiety- and Depressive-like Effects of Paclitaxel in Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. PTX-Derived Peripheral Neuropathy Induction
2.3. Nociceptive Tests
2.4. Emotional Behavior Tests
2.5. Western Blot Analysis
2.6. Experimental Procedures
2.7. Drugs
2.8. Statistical Analyses
3. Results
3.1. Treatment with CoPP Inhibited the Mechanical and Cold Allodynia Caused by PTX
3.2. CoPP Treatment Prevented the Emotional Behavioral Alterations Associated with PIPN
3.3. GYY4137 Inhibited the Mechanical and Cold Allodynia Induced by PTX
3.4. GYY4137 Administration Relieved PIPN-Derived Affective Disorders
3.5. Effects of CoPP and GYY4137 on the Expression of MAPK and PI3K/p-Akt in PFC and DRG of PTX-Injected Mice
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Roch, G.; Batallé, G.; Bai, X.; Pouso-Vázquez, E.; Rodríguez, L.; Pol, O. The Beneficial Effects of Heme Oxygenase 1 and Hydrogen Sulfide Activation in the Management of Neuropathic Pain, Anxiety- and Depressive-like Effects of Paclitaxel in Mice. Antioxidants 2022, 11, 122. https://doi.org/10.3390/antiox11010122
Roch G, Batallé G, Bai X, Pouso-Vázquez E, Rodríguez L, Pol O. The Beneficial Effects of Heme Oxygenase 1 and Hydrogen Sulfide Activation in the Management of Neuropathic Pain, Anxiety- and Depressive-like Effects of Paclitaxel in Mice. Antioxidants. 2022; 11(1):122. https://doi.org/10.3390/antiox11010122
Chicago/Turabian StyleRoch, Gerard, Gerard Batallé, Xue Bai, Enric Pouso-Vázquez, Laura Rodríguez, and Olga Pol. 2022. "The Beneficial Effects of Heme Oxygenase 1 and Hydrogen Sulfide Activation in the Management of Neuropathic Pain, Anxiety- and Depressive-like Effects of Paclitaxel in Mice" Antioxidants 11, no. 1: 122. https://doi.org/10.3390/antiox11010122
APA StyleRoch, G., Batallé, G., Bai, X., Pouso-Vázquez, E., Rodríguez, L., & Pol, O. (2022). The Beneficial Effects of Heme Oxygenase 1 and Hydrogen Sulfide Activation in the Management of Neuropathic Pain, Anxiety- and Depressive-like Effects of Paclitaxel in Mice. Antioxidants, 11(1), 122. https://doi.org/10.3390/antiox11010122