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Brain Sci. 2018, 8(4), 49;

Diagnosis and Surgical Treatment of Drug-Resistant Epilepsy

Department of Neurology, Virginia Tech Carilion School of Medicine, Roanoke, VA 24016, USA
Department of Neurology, Georgetown University Medical Center, Washington, DC 20007, USA
Author to whom correspondence should be addressed.
Received: 24 November 2017 / Revised: 12 March 2018 / Accepted: 16 March 2018 / Published: 21 March 2018
(This article belongs to the Special Issue Diagnosis and Surgical Treatment of Epilepsy)
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Despite appropriate trials of at least two antiepileptic drugs, about a third of patients with epilepsy remain drug resistant (intractable; refractory). Epilepsy surgery offers a potential cure or significant improvement to those with focal onset drug-resistant seizures. Unfortunately, epilepsy surgery is still underutilized which might be in part because of the complexity of presurgical evaluation. This process includes classifying the seizure type, lateralizing and localizing the seizure onset focus (epileptogenic zone), confirming the safety of the prospective brain surgery in terms of potential neurocognitive deficits (language and memory functions), before devising a surgical plan. Each one of the above steps requires special tests. In this paper, we have reviewed the process of presurgical evaluation in patients with drug-resistant focal onset epilepsy. View Full-Text
Keywords: medically intractable epilepsy; EEG; epilepsy surgery; MRI; epilepsy; seizures medically intractable epilepsy; EEG; epilepsy surgery; MRI; epilepsy; seizures

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Anyanwu, C.; Motamedi, G.K. Diagnosis and Surgical Treatment of Drug-Resistant Epilepsy. Brain Sci. 2018, 8, 49.

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