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Integrating Spatial Working Memory and Remote Memory: Interactions between the Medial Prefrontal Cortex and Hippocampus

Department of Psychology, University of Nevada Las Vegas, 4505 S. Maryland Pkwy, Las Vegas, NV 89154, USA
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Academic Editor: Sven Kroener
Brain Sci. 2017, 7(4), 43; https://doi.org/10.3390/brainsci7040043
Received: 24 January 2017 / Revised: 11 April 2017 / Accepted: 14 April 2017 / Published: 18 April 2017
In recent years, two separate research streams have focused on information sharing between the medial prefrontal cortex (mPFC) and hippocampus (HC). Research into spatial working memory has shown that successful execution of many types of behaviors requires synchronous activity in the theta range between the mPFC and HC, whereas studies of memory consolidation have shown that shifts in area dependency may be temporally modulated. While the nature of information that is being communicated is still unclear, spatial working memory and remote memory recall is reliant on interactions between these two areas. This review will present recent evidence that shows that these two processes are not as separate as they first appeared. We will also present a novel conceptualization of the nature of the medial prefrontal representation and how this might help explain this area’s role in spatial working memory and remote memory recall. View Full-Text
Keywords: hippocampus; medial prefrontal cortex; spatial working memory; remote memory; Theta hippocampus; medial prefrontal cortex; spatial working memory; remote memory; Theta
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Wirt, R.A.; Hyman, J.M. Integrating Spatial Working Memory and Remote Memory: Interactions between the Medial Prefrontal Cortex and Hippocampus. Brain Sci. 2017, 7, 43.

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