Next Article in Journal
Systematic Review of Cognitive-Behavioural Therapy for Social Anxiety Disorder in Psychosis
Previous Article in Journal
Integrating Spatial Working Memory and Remote Memory: Interactions between the Medial Prefrontal Cortex and Hippocampus
Article Menu

Export Article

Open AccessReview
Brain Sci. 2017, 7(4), 44;

A Comprehensive Diverse ‘-omics’ Approach to Better Understanding the Molecular Pathomechanisms of Down Syndrome

Department of Pathological Biochemistry, Division of Pathological Science, Kyoto Pharmaceutical University, 5 Misasagi Nakauchi-cho, Ymashina-ku, Kyoto 607-8414, Japan
Author to whom correspondence should be addressed.
Academic Editor: Bruno Meloni
Received: 28 March 2017 / Revised: 17 April 2017 / Accepted: 18 April 2017 / Published: 21 April 2017
Full-Text   |   PDF [616 KB, uploaded 21 April 2017]   |  


Diverse ‘-omics’ technologies permit the comprehensive quantitative profiling of a variety of biological molecules. Comparative ‘-omics’ analyses, such as transcriptomics and proteomics, are powerful and useful tools for unraveling the molecular pathomechanisms of various diseases. As enhanced oxidative stress has been demonstrated in humans and mice with Down syndrome (DS), a redox proteomic analysis is useful for understanding how enhanced oxidative stress aggravates the state of individuals with oxidative stress-related disorders. In this review, ‘-omics’ analyses in humans with DS and mouse models of DS are summarized, and the molecular dissection of this syndrome is discussed. View Full-Text
Keywords: proteomics; transcriptomics; Down syndrome; mouse models proteomics; transcriptomics; Down syndrome; mouse models

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Ishihara, K.; Akiba, S. A Comprehensive Diverse ‘-omics’ Approach to Better Understanding the Molecular Pathomechanisms of Down Syndrome. Brain Sci. 2017, 7, 44.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top