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Article

Impact of SAfinamide on Depressive Symptoms in Parkinson’s Disease Patients (SADness-PD Study): A Multicenter Retrospective Study

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Neurology Department, Hospital La Moraleja, 28050 Madrid, Spain
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Neurology Department, Hospital Infanta Sofía, 28703 Madrid, Spain
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Neurology Department, Hospital Ramón y Cajal, 28034 Madrid, Spain
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Neurology Department, Hospital La Princesa, 28006 Madrid, Spain
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Neurology Department, Complejo Hospitalario Ruber Juan Bravo, 28006 Madrid, Spain
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Neurology Department, Hospital Infanta Leonor, 28031 Madrid, Spain
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Neurology Department, Hospital Quironsalud Madrid, 28223 Madrid, Spain
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Neurology Department, Clínica del Rosario, 28006 Madrid, Spain
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Author to whom correspondence should be addressed.
Academic Editor: Lucia Ricciardi
Brain Sci. 2021, 11(2), 232; https://doi.org/10.3390/brainsci11020232
Received: 9 January 2021 / Revised: 24 January 2021 / Accepted: 10 February 2021 / Published: 13 February 2021
Background: We aimed to assess the effects of safinamide on depression, motor symptoms, and the serotonin syndrome related to its co-administration with antidepressants in patients with Parkinson’s disease (PD). Methods: We retrospectively analyzed the data of patients at 1 and 3 months of follow-up compared to baseline. Results: n = 82 (safinamide 50 mg = 22, 100 mg = 60, with antidepressants = 44). First, we found improvement in depression (Hamilton Depression Rating Scale: −6 ± 5.10 at 1 month and −7.27 ± 5.10 at 3 months, p < 0.0001; Patient Global Impression of Improvement Scale: 60.3% and 69.5% of patients at 1 and 3 months reported some improvement). Second, safinamide improved the daily life activities and motor symptoms/motor complications (Unified Parkinson’s Disease Rating Scale (UPDRS-II): −2.51 ± 6.30 and −2.47 ± 6.11 at 1 and 3 months, p < 0.0001; III: −3.58 ± 8.68 and −4.03 ± 8.95 at 1 and 3 months, p < 0.0001; IV: −0.61 ± 2.61 and −0.8 ± 2.53 at 1 and 3 months, p < 0.0001). Third, 7.31% and 8.53% of patients developed non-severe adverse events related to safinamide at 1 and 3 months. Serotonin syndrome was not observed in the patients treated with antidepressants; some isolated serotonin syndrome symptoms were reported. Conclusions: Safinamide could be useful for treating depression in PD; it was effective for motor symptoms and motor complications and safe even when co-administered with antidepressants. View Full-Text
Keywords: Parkinson’s disease; depression; serotonin syndrome; antidepressants; safinamide; motor symptoms Parkinson’s disease; depression; serotonin syndrome; antidepressants; safinamide; motor symptoms
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MDPI and ACS Style

Peña, E.; Borrué, C.; Mata, M.; Martínez-Castrillo, J.C.; Alonso-Canovas, A.; Chico, J.L.; López-Manzanares, L.; Llanero, M.; Herreros-Rodríguez, J.; Esquivel, A.; Maycas-Cepeda, T.; Ruíz-Huete, C. Impact of SAfinamide on Depressive Symptoms in Parkinson’s Disease Patients (SADness-PD Study): A Multicenter Retrospective Study. Brain Sci. 2021, 11, 232. https://doi.org/10.3390/brainsci11020232

AMA Style

Peña E, Borrué C, Mata M, Martínez-Castrillo JC, Alonso-Canovas A, Chico JL, López-Manzanares L, Llanero M, Herreros-Rodríguez J, Esquivel A, Maycas-Cepeda T, Ruíz-Huete C. Impact of SAfinamide on Depressive Symptoms in Parkinson’s Disease Patients (SADness-PD Study): A Multicenter Retrospective Study. Brain Sciences. 2021; 11(2):232. https://doi.org/10.3390/brainsci11020232

Chicago/Turabian Style

Peña, Esteban, Carmen Borrué, Marina Mata, Juan Carlos Martínez-Castrillo, Araceli Alonso-Canovas, Juan Luis Chico, Lydia López-Manzanares, Marcos Llanero, Jaime Herreros-Rodríguez, Alberto Esquivel, Teresa Maycas-Cepeda, and Cristina Ruíz-Huete. 2021. "Impact of SAfinamide on Depressive Symptoms in Parkinson’s Disease Patients (SADness-PD Study): A Multicenter Retrospective Study" Brain Sciences 11, no. 2: 232. https://doi.org/10.3390/brainsci11020232

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