Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition
Abstract
1. Introduction
2. Materials and Methods
2.1. Participants
2.2. MRI Acquisition
2.3. MRI Processing
2.3.1. Diffusion MRI Preprocessing
2.3.2. Calculation of the Diffusion Measures
2.3.3. Tract-Based Spatial Statistics (TBSS)
2.4. Statistical Analysis
3. Results
3.1. TBSS
3.2. TBSS with Covariates
3.3. Correlation Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Appendix A
Appendix B
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Middle cerebellar peduncle | 0.023 | 1295 | (−20,−50,−32) |
Superior cerebellar peduncle R/L | 0.028/0.030 | 101/115 | (5,−28,−19)/(−4,−28,−19) |
Inferior cerebellar peduncle L | 0.035 | 46 | (−10,−50,−25) |
Superior longitudinal fasciculus R | 0.033 | 720 | (32,−4,20) |
Splenium of corpus callosum | 0.042 | 32 | (18,−49,27) |
Superior corona radiata R/L | 0.030/0.032 | 335/136 | (28,−15,19)/(−27,−11,20) |
Posterior corona radiata R | 0.035 | 83 | (28,−34,19) |
External capsule R/L | 0.033/0.031 | 127/171 | (30,−10,14)/(−28,−10,18) |
Posterior limb of internal capsule R/L | 0.029/0.032 | 301/281 | (26,−17,13)/(−27,−17,17) |
Retrolenticular part of internal capsule R/L | 0.031/0.032 | 473/59 | (30,−29,7)/(−25,−23,12) |
Sagittal stratum R | 0.034 | 150 | (38,−28,−4) |
Posterior thalamic radiation R | 0.034 | 51 | (30,−39,16) |
Cerebral peduncle R/L | 0.028/0.031 | 207/258 | (10,−28,−16)/(−9,−20,−20) |
Corticospinal tract R/L | 0.030/0.031 | 105/125 | (11,−22,−22)/(−7,−18,−22) |
Pontine crossing tract | 0.030 | 56 | (4,−26,−24) |
Fornix (cres) R | 0.037 | 46 | (35,−12,−14) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Superior corona radiata L | 0.026 | 116 | (−26,−11,20) |
External capsule L | 0.022 | 303 | (−34,−15,−8) |
Posterior limb of internal capsule L | 0.024 | 472 | (−15,10,0) |
Retrolenticular part of internal capsule L | 0.025 | 347 | (−33,−34,6) |
Sagittal stratum L | 0.023 | 133 | (−36,−17,−9) |
Posterior thalamic radiation L | 0.025 | 38 | (−35,−39,7) |
Cerebral peduncle L | 0.024 | 105 | (−15,−13,−5) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Superior longitudinal fasciculus R | 0.033 | 271 | (32,−4,19) |
Body of corpus callosum | 0.042 | 47 | (19,−30,31) |
Splenium of corpus callosum | 0.042 | 209 | (19,−31,31) |
Anterior corona radiata R | 0.033 | 295 | (25,17,12) |
Superior corona radiata R | 0.038 | 236 | (32,−6,20) |
Posterior corona radiata R | 0.039 | 133 | (25,−23,22) |
External capsule R | 0.031 | 661 | (30,1,13) |
Posterior limb of internal capsule R | 0.039 | 217 | (24,−19,1) |
Retrolenticular part of internal capsule R | 0.036 | 425 | (38,−29,0) |
Anterior limb of internal capsule R | 0.035 | 83 | (23,17,11) |
Sagittal stratum R | 0.036 | 132 | (33,−23,−4) |
Fornix (cres) R | 0.035 | 36 | (33,−22,−6) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Superior corona radiata R/L | 0.046/0.040 | 50/87 | (20,−28,40)/(−26,−11,19) |
External capsule L | 0.033 | 278 | (−33,−11,1) |
Anterior limb of internal capsule L | 0.044 | 31 | (−18,2,12) |
Posterior limb of internal capsule L | 0.034 | 377 | (−23,−22,3) |
Retrolenticular part of internal capsule L | 0.034 | 315 | (−30,−23,2) |
Sagittal stratum L | 0.034 | 114 | (−36,−17,−9) |
Cerebral peduncle L | 0.036 | 37 | (−14,−12,−5) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Superior longitudinal fasciculus R | 0.046 | 179 | (39,−9,26) |
External capsule R | 0.044 | 244 | (33,−14,−3) |
Retrolenticular part of internal capsule R | 0.045 | 157 | (34,−21,−2) |
Sagittal stratum R | 0.045 | 194 | (39,−18,−12) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Middle cerebellar peduncle | 0.047 | 31 | (−21,−65,−40) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Middle cerebellar peduncle | 0.026 | 439 | (−23,−55,−42) |
Superior longitudinal fasciculus R/L | 0.045/0.039 | 52/464 | (33,1,27)/(−36,−4,−18) |
Anterior corona radiata L | 0.042 | 66 | (−23,16,27) |
Superior corona radiata L | 0.041 | 160 | (−26,4,26) |
Posterior corona radiata L | 0.039 | 42 | (−29,−60,21) |
External capsule R | 0.018 | 36 | (36,−16,−9) |
Retrolenticular part of internal capsule R/L | 0.019/0.043 | 239/40 | (39,−38,−3)/(−39,−33,−1) |
Sagittal stratum R/L | 0.012/0.036 | 387/194 | (44,−29,−14)/(−40,−33,−6) |
Posterior thalamic radiation R/L | 0.015/0.039 | 188/176 | (39,−41,−2)/(−30,−65,17) |
Fornix (cres) R | 0.017 | 75 | (35,−16,−12) |
Cingulum (hippocampus) R | 0.017 | 68 | (29,−18,27) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Superior longitudinal fasciculus R/L | 0.012/0.012 | 950/1030 | (38,−35,31)/(−35,−35,27) |
Genu of corpus callosum | 0.012 | 653 | (18,20,25) |
Body of corpus callosum | 0.012 | 1440 | (16,16,29) |
Splenium of corpus callosum | 0.009 | 1170 | (26,−58,12) |
Anterior corona radiata R/L | 0.011/0.012 | 1147/980 | (26,16,25)/(−25,18,21) |
Superior corona radiata R/L | 0.011/0.012 | 904/820 | (25,12,28)/(−25,6,28) |
Posterior corona radiata R/L | 0.009/0.012 | 265/246 | (28,−63,19)/(−30,−60,21) |
External capsule R/L | 0.012/0.012 | 549/576 | (30,11,−1)/(−25,10,14) |
Posterior limb of internal capsule R/L | 0.012/0.016 | 390/261 | (23,−6,17)/(−22,−10,16) |
Retrolenticular part of internal capsule R/L | 0.012/0.016 | 390/271 | (30,−38,17)/(−38,−33,0) |
Anterior limb of internal capsule R/L | 0.012/0.012 | 229/416 | (22,8,13)/(−20,9,13) |
Sagittal stratum R/L | 0.014/0.016 | 444/309 | (44,−30,−15)/(−40,−28,−7) |
Posterior thalamic radiation R/L | 0.008/0.012 | 601/470 | (29,−61,13)/(−30,−66,−16) |
Fornix (cres) R/L | 0.015/0.018 | 171/177 | (33,−7,−19)/(−35,−11,−17) |
Cingulum R/L | 0.014/0.016 | 53/135 | (10,−46,22)/(−10,−40,28) |
Cingulum (hippocampus) R/L | 0.018/0.019 | 84/67 | (24,−29,−15)/(−19,−38,−7) |
Superior fronto-occipital fasciculus R/L | 0.012/0.012 | 59/46 | (22,−1,21)/(−21,1,20) |
Uncinate fasciculus R | 0.025 | 35 | (34,0,−15) |
Tapetum R/L | 0.009/0.016 | 82/75 | (31,−52,14)/(−28,−50,16) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Middle cerebellar peduncle | 0.033 | 694 | (−6,−19,−32) |
Superior cerebellar peduncle R/L | 0.033/0.034 | 66/49 | (6,−29,−19)/(−7,−34,−23) |
Inferior cerebellar peduncle L | 0.040 | 113 | (−11,−46,−29) |
Superior longitudinal fasciculus R/L | 0.016/0.019 | 610/722 | (35,−44,26)/(−32,7,22) |
Genu of corpus callosum | 0.018 | 905 | (−13,22,18) |
Body of corpus callosum | 0.018 | 1783 | (−13,18,21) |
Splenium of corpus callosum | 0.015 | 1680 | (25,−53,19) |
Anterior corona radiata R/L | 0.018/0.019 | 972/555 | (25,15,28)/(−25,13,23) |
Superior corona radiata R/L | 0.018/0.019 | 710/793 | (25,12,28)/(−24,5,20) |
Posterior corona radiata R/L | 0.014/0.019 | 291/287 | (28,−63,19)/(−18,−40,36) |
External capsule R/L | 0.019/0.019 | 408/250 | (26,17,7)/(−25,10,14) |
Posterior limb of internal capsule R/L | 0.020/0.019 | 297/390 | (23,−6,17)/(−22,−10,16) |
Retrolenticular part of internal capsule R/L | 0.030/0.038 | 223/131 | (29,−37,17)/(−38,−33,0) |
Anterior limb of internal capsule R/L | 0.019/0.019 | 319/436 | (22,18,9)/(−21,14,13) |
Sagittal stratum R/L | 0.020/0.039 | 252/204 | (38,−15,−12)/(−40,−28,−7) |
Posterior thalamic radiation R/L | 0.014/0.022 | 529/364 | (28,−64,18)/(−30,−66,16) |
Cerebral peduncle R/L | 0.033/0.032 | 233/323 | (10,−29,−16)/(−8,−18,−20) |
Corticospinal tract R/L | 0.034/0.033 | 99/205 | (11,−25,−22)/(−7,−21,−27) |
Medial lemniscus R/L | 0.034/0.034 | 36/68 | (6,−33,−30)/(−4,−33,−26) |
Pontine crossing tract | 0.033 | 217 | (6,−30,−30) |
Fornix (cres) R | 0.020 | 164 | (33,7,−19) |
Cingulum R/L | 0.029/0.019 | 43/160 | (10,−46,22)/(−10,−40,28) |
Superior fronto-occipital fasciculus R/L | 0.020/0.019 | 61/54 | (22,6,20)/(−21,1,20) |
Uncinate fasciculus R | 0.039 | 43 | (34,0,−18) |
Tapetum R/L | 0.015/0.021 | 78/100 | (31,−52,14)/(−26,−49,19) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Superior cerebellar peduncle R | 0.043 | 49 | (4,−29,−17) |
Superior longitudinal fasciculus R/L | 0.009/0.007 | 667/711 | (33,−40,29)/(−28,−44,31) |
Genu of corpus callosum | 0.010 | 1005 | (−14,23,19) |
Body of corpus callosum | 0.007 | 1749 | (−17,−23,34) |
Splenium of corpus callosum | 0.007 | 1192 | (−23,−52,19) |
Anterior corona radiata R/L | 0.009/0.007 | 1145/728 | (27,12,23)/(−24,13,15) |
Superior corona radiata R/L | 0.009/0.007 | 966/991 | (26,8,25)/(−26,−18,28) |
Posterior corona radiata R/L | 0.007/0.007 | 350/392 | (28,−63,16)/(−26,−62,16) |
External capsule R/L | 0.009/0.007 | 426/362 | (26,16,9)/(−24,15,10) |
Posterior limb of internal capsule R/L | 0.011/0.008 | 363/277 | (20,−4,12)/(−22,−11,14) |
Retrolenticular part of internal capsule R/L | 0.011/0.011 | 234/276 | (30,−38,17)/(−37,−34,2) |
Anterior limb of internal capsule R/L | 0.009/0.007 | 337/440 | (22,7,15)/(−21,14,13) |
Sagittal stratum R/L | 0.029/0.011 | 267/189 | (40,−14,−16)/(−41,−26,−8) |
Posterior thalamic radiation R/L | 0.007/0.008 | 512/303 | (28,−63,16)/(−26,−62,16) |
Pontine crossing tract | 0.044 | 182 | (−2,−31,−35) |
Fornix (cres) R/L | 0.030/0.013 | 182/191 | (35,−8,−19)/(−35,−11,−17) |
Cingulum R/L | 0.018/0.011 | 35/141 | (10,−34,35)/(−9,−39,29) |
Superior fronto-occipital fasciculus R/L | 0.009/0.007 | 85/61 | (22,6,19)/(−21,1,20) |
Uncinate fasciculus R | 0.020 | 43 | (34,1,−15) |
Tapetum R/L | 0.008/0.008 | 82/75 | (31,−52,14)/(−28,−48,20) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Middle cerebellar peduncle | 0.032 | 85 | (9,−21,−39) |
Superior cerebellar peduncle R/L | 0.043/0.043 | 59/42 | (4,−29,−17)/(−7,−34,−23) |
Superior longitudinal fasciculus R/L | 0.032/0.021 | 60/54 | (34,−45,28)/(−28,−44,31) |
Genu of corpus callosum | 0.033 | 890 | (−13,23,19) |
Body of corpus callosum | 0.021 | 1633 | (−17,−24,34) |
Splenium of corpus callosum | 0.021 | 1612 | (−23,−52,19) |
Anterior corona radiata R/L | 0.031/0.021 | 919/498 | (27,12,23)/(−24,13,15) |
Superior corona radiata R/L | 0.029/0.021 | 672/804 | (19,−23,36)/(−24,3,20) |
Posterior corona radiata R/L | 0.021/0.021 | 299/327 | (28,−63,19)/(−23,−32,32) |
External capsule R/L | 0.032/0.021 | 81/157 | (26,16,8)/(−26,10,14) |
Posterior limb of internal capsule R/L | 0.011/0.008 | 300/420 | (19,−11,2)/(−22,−10,14) |
Retrolenticular part of internal capsule L | 0.028 | 127 | (−36,−34,1) |
Anterior limb of internal capsule R/L | 0.009/0.007 | 364/432 | (23,18,8)/(−22,6,18) |
Sagittal stratum R/L | 0.032/0.029 | 207/165 | (40,−42,−5)/(−40,−28,−7) |
Posterior thalamic radiation R/L | 0.021/0.023 | 510/245 | (28,−63,16)/(−27,−63,18) |
Cerebral peduncle R/L | 0.032/0.031 | 227/319 | (10,−29,−15)/(−17,−16,−6) |
Corticospinal tract R/L | 0.032/0.032 | 107/141 | (6,−28,−40)/(−7,−20,−24) |
Medial lemniscus R/L | 0.032/0.032 | 34/61 | (6,−33,−30)/(−4,−33,−26) |
Pontine crossing tract | 0.032 | 204 | (−2,−31,−35) |
Cingulum L | 0.022 | 162 | (−9,−39,29) |
Cingulum (hippocampus) R | 0.042 | 40 | (24,−29,−15) |
Superior fronto-occipital fasciculus R/L | 0.032/0.021 | 60/54 | (22,5,19)/(−21,1,20) |
Tapetum R/L | 0.023/0.021 | 82/104 | (31,−52,14)/(−25,−46,20) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Superior longitudinal fasciculus L | 0.042 | 135 | (−29,−25,37) |
Superior corona radiata L | 0.040 | 244 | (−22,−23,41) |
External capsule L | 0.033 | 281 | (−35,−16,−8) |
Posterior limb of internal capsule L | 0.031 | 430 | (−16,−8,4) |
Retrolenticular part of internal capsule L | 0.035 | 297 | (−33,−35,6) |
Anterior limb of internal capsule L | 0.035 | 37 | (−11,0,2) |
Sagittal stratum L | 0.034 | 153 | (−40,−29,−6) |
Cerebral peduncle L | 0.033 | 98 | (−15,−13,−5) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Superior longitudinal fasciculus L | 0.046 | 32 | (−41,−38,4) |
External capsule L | 0.046 | 127 | (−34,−14,−8) |
Posterior limb of internal capsule L | 0.044 | 277 | (−16,−8,4) |
Retrolenticular part of internal capsule L | 0.047 | 202 | (−30,−23,2) |
Sagittal stratum L | 0.042 | 83 | (−40,−30,−5) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Superior longitudinal fasciculus R | 0.037 | 78 | (35,−44,26) |
Genu of corpus callosum | 0.037 | 387 | (−14,21,21) |
Body of corpus callosum | 0.037 | 463 | (−12,19,21) |
Splenium of corpus callosum | 0.034 | 87 | (25,−53,19) |
Anterior corona radiata R | 0.042 | 91 | (17,24,24) |
Superior corona radiata R/L | 0.049/0.046 | 258/48 | (20,−30,41)/(−22,−20,36) |
Posterior corona radiata R | 0.020 | 285 | (20,−30,39) |
Posterior thalamic radiation R | 0.034 | 100 | (28,−56,17) |
Tapetum R | 0.034 | 94 | (30,−46,17) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Superior longitudinal fasciculus R/L | 0.038/0.046 | 218/127 | (35,−48,25)/(−29,−45,31) |
Genu of corpus callosum | 0.033 | 566 | (−14,21,21) |
Body of corpus callosum | 0.033 | 985 | (−12,19,21) |
Splenium of corpus callosum | 0.035 | 314 | (25,−52,22) |
Anterior corona radiata R/L | 0.040/0.038 | 144/188 | (17,27,21)/(−15,16,30) |
Superior corona radiata R | 0.037 | 337 | (20,−29,41) |
Posterior corona radiata R/L | 0.035/0.046 | 311/120 | (28,−55,20)/(−29,−57,21) |
Posterior thalamic radiation R/L | 0.035/0.046 | 389/38 | (28,−63,17)/(−31,−52,16) |
Tapetum R/L | 0.038/0.044 | 95/69 | (30,−47,17)/(−26,−51,18) |
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HC (n = 50) | EM (n = 54) | CM (n = 56) | Statistical Test | |
---|---|---|---|---|
Gender, male/female | 11/39 (22/78%) | 9/45 (17/83%) | 6/50 (11/89%) | χ2(2, N = 160) = 2.48, p = 0.29 † |
Age (years) | 36.1 ± 13.2 | 37.1 ± 8.2 | 38.1 ± 8.7 | χ2 (2) = 2.85, p = 0.24 ‡ |
Duration of the migraine history (years) | 14.1 ± 11.1 | 19.6 ± 10.4 | t(108) = −2.7, p = 0.008 § | |
Time from onset of CM (months) | 24.5 ± 32.9 | |||
Headache frequency (days/month) | 3.6 ± 1.9 | 23.3 ± 6.3 | U = 44.0, p < 0.001 ⁋ | |
Migraine frequency (days/month) | 3.6 ± 1.9 | 13.9 ± 6.9 | U = 108.5, p < 0.001 ⁋ | |
Overusing medication | 0 (0%) | 42 (75%) | p < 0.001 ⁑ | |
Aura | 9 (17%) | 1 (2%) | p = 0.007 ⁑ |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Middle cerebellar peduncle | 0.007 | 2206 | (−20,−50,−32) |
Superior cerebellar peduncle R/L | 0.020/0.020 | 142/126 | (5,−28,−19)/(−4,−28,−19) |
Inferior cerebellar peduncle R/L | 0.019/0.009 | 75/89 | (12,−43,−35)/(−13,−45,−31) |
Superior longitudinal fasciculus R/L | 0.021/0.021 | 971/874 | (33,−4,20)/(−36,−49,15) |
Genu of corpus callosum | 0.019 | 455 | (10,−28,1) |
Body of corpus callosum | 0.032 | 842 | (−4,30,23) |
Splenium of corpus callosum | 0.025 | 873 | (22,−50,25) |
Anterior corona radiata R/L | 0.024/0.018 | 556/805 | (18,21,−11)/(−18,38,−1) |
Superior corona radiata R/L | 0.020/0.022 | 666/396 | (28,−16,21)/(−27,−11,20) |
Posterior corona radiata R/L | 0.022/0.022 | 201/214 | (25,−24,24)/(−30,−52,22) |
External capsule R/L | 0.020/0.018 | 459/695 | (30,−10,14)/(−22,16,−12) |
Posterior limb of internal capsule R/L | 0.020/0.022 | 569/536 | (26,−17,13)/(−27,−17,17) |
Retrolenticular part of internal capsule R/L | 0.023/0.023 | 457/344 | (31,−34,15)/(−25,−22,3) |
Anterior limb of internal capsule R/L | 0.022/0.020 | 216/290 | (15,−1,7)/(−20,18,3) |
Sagittal stratum R/L | 0.022/0.022 | 471/359 | (37,−49,−4)/(−41,−18,−13) |
Posterior thalamic radiation R/L | 0.022/0.022 | 353/279 | (37,−50,−2)/(−35,−52,13) |
Cerebral peduncle R/L | 0.020/0.022 | 234/265 | (11,−23,−21)/(−9,−19,−20) |
Corticospinal tract R/L | 0.019/0.023 | 106/165 | (10,−27,−26)/(−7,−18,−22) |
Medial lemniscus R/L | 0.020/0.015 | 82/103 | (8,−39,−40)/(−7,−37,−40) |
Pontine crossing tract | 0.018 | 82 | (8,−31,−27) |
Fornix (cres) R/L | 0.024/0.024 | 74/45 | (35,−12,−14)/(−34,−15,−13) |
Cingulum (hippocampus) L | 0.036 | 56 | (−17,−42,−2) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Anterior thalamic radiation L/R | 0.020/0.021 | 316/232 | (−21,18,3)/(9,−29,−14) |
Corticospinal tract L/R | 0.022/0.018 | 627/601 | (−24,−20,9)/(10,−28,−26) |
Cingulum (hippocampus) L | 0.036 | 37 | (−17,−43,−2) |
Forceps major | 0.024 | 375 | (−18,−85,8) |
Forceps minor | 0.018 | 1601 | (−17,39,−2) |
Inferior fronto-occipital fasciculus L/R | 0.018/0.022 | 994/973 | (−23,27,3)/(37,−49,−4) |
Inferior longitudinal fasciculus L/R | 0.022/0.022 | 418/507 | (−35,−52,12)/(44,−33,−12) |
Superior longitudinal fasciculus L/R | 0.021/0.021 | 1023/828 | (−36,−50,14)/(31,−6,17) |
Superior longitudinal fasciculus (temporal part) R | 0.022 | 62 | (49,−33,−11) |
Uncinate fasciculus L | 0.018 | 83 | (−18,21,−9) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Middle cerebellar peduncle | 0.042 | 908 | (13,−30,−26) |
Superior cerebellar peduncle R/L | 0.042/0.042 | 65/65 | (7,−32,−19)/(−5,−31,−18) |
Inferior cerebellar peduncle L | 0.045 | 96 | (−13,−45,−31) |
Genu of corpus callosum | 0.047 | 44 | (18,31,15) |
Anterior corona radiata R | 0.044 | 446 | (26,35,−1) |
Superior corona radiata R | 0.048 | 84 | (23,−12,19) |
External capsule R/L | 0.042/0.046 | 415/392 | (33,−19,−2)/(−33,−13,1) |
Posterior limb of internal capsule R/L | 0.042/0.046 | 285/420 | (20,−20,−4)/(−22,−8,14) |
Retrolenticular part of internal capsule R/L | 0.041/0.044 | 244/314 | (37,−26,−2)/(−37,−34,2) |
Anterior limb of internal capsule L | 0.046 | 43 | (−17,−2,12) |
Sagittal stratum R/L | 0.041/0.044 | 243/97 | (39,−29,−5)/(−40,−29,−6) |
Cerebral peduncle R | 0.042 | 254 | (12,−25,−21) |
Corticospinal tract R/L | 0.042/0.042 | 156/135 | (11,−25,−22)/(−7,−25,−26) |
Medial lemniscus R/L | 0.045/0.046 | 83/87 | (9,−32,−25)/(−4,−37,−30) |
Pontine crossing tract | 0.042 | 163 | (−4,−30,−28) |
Fornix (cres) R | 0.041 | 148 | (32,−22,−6) |
Uncinate fasciculus R | 0.043 | 32 | (35,−4,−14) |
White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
---|---|---|---|
Anterior thalamic radiation L/R | 0.046/0.042 | 34/68 | (−7,−36,−27)/(9,−29,−14) |
Corticospinal tract L/R | 0.042/0.042 | 284/374 | (−7,−25,−26)/(11,−25,−22) |
Forceps minor | 0.046 | 342 | (19,38,16) |
Inferior fronto-occipital fasciculus L/R | 0.044/0.044 | 240/676 | (−39,−30,−4)/(37,−27,−3) |
Inferior longitudinal fasciculus L/R | 0.043/0.042 | 309/167 | (−41,−28,−4)/(42,−14,−14) |
Uncinate fasciculus L/R | 0.048/0.044 | 62/71 | (−35,−2,−20)/(34,1,−16) |
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Planchuelo-Gómez, Á.; García-Azorín, D.; Guerrero, Á.L.; de Luis-García, R.; Rodríguez, M.; Aja-Fernández, S. Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition. Brain Sci. 2020, 10, 711. https://doi.org/10.3390/brainsci10100711
Planchuelo-Gómez Á, García-Azorín D, Guerrero ÁL, de Luis-García R, Rodríguez M, Aja-Fernández S. Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition. Brain Sciences. 2020; 10(10):711. https://doi.org/10.3390/brainsci10100711
Chicago/Turabian StylePlanchuelo-Gómez, Álvaro, David García-Azorín, Ángel L. Guerrero, Rodrigo de Luis-García, Margarita Rodríguez, and Santiago Aja-Fernández. 2020. "Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition" Brain Sciences 10, no. 10: 711. https://doi.org/10.3390/brainsci10100711
APA StylePlanchuelo-Gómez, Á., García-Azorín, D., Guerrero, Á. L., de Luis-García, R., Rodríguez, M., & Aja-Fernández, S. (2020). Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition. Brain Sciences, 10(10), 711. https://doi.org/10.3390/brainsci10100711