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Open AccessArticle

Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition

1
Imaging Processing Laboratory, Universidad de Valladolid, 47011 Valladolid, Spain
2
Headache Unit, Department of Neurology, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain
3
Institute for Biomedical Research of Salamanca, 37007 Salamanca, Spain
4
Deparment of Medicine, Universidad de Valladolid, 47005 Valladolid, Spain
5
Deparment of Radiology, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(10), 711; https://doi.org/10.3390/brainsci10100711
Received: 29 August 2020 / Revised: 29 September 2020 / Accepted: 2 October 2020 / Published: 6 October 2020
The white matter state in migraine has been investigated using diffusion tensor imaging (DTI) measures, but results using this technique are conflicting. To overcome DTI measures, we employed ensemble average diffusion propagator measures obtained with apparent measures using reduced acquisitions (AMURA). The AMURA measures were return-to-axis (RTAP), return-to-origin (RTOP) and return-to-plane probabilities (RTPP). Tract-based spatial statistics was used to compare fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity from DTI, and RTAP, RTOP and RTPP, between healthy controls, episodic migraine and chronic migraine patients. Fifty healthy controls, 54 patients with episodic migraine and 56 with chronic migraine were assessed. Significant differences were found between both types of migraine, with lower axial diffusivity values in 38 white matter regions and higher RTOP values in the middle cerebellar peduncle in patients with a chronic migraine (p < 0.05 family-wise error corrected). Significantly lower RTPP values were found in episodic migraine patients compared to healthy controls in 24 white matter regions (p < 0.05 family-wise error corrected), finding no significant differences using DTI measures. The white matter microstructure is altered in a migraine, and in chronic compared to episodic migraine. AMURA can provide additional results with respect to DTI to uncover white matter alterations in migraine. View Full-Text
Keywords: migraine; chronic migraine; diffusion tensor imaging; magnetic resonance imaging (MRI); tract-based spatial statistics; diffusion magnetic resonance imaging migraine; chronic migraine; diffusion tensor imaging; magnetic resonance imaging (MRI); tract-based spatial statistics; diffusion magnetic resonance imaging
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MDPI and ACS Style

Planchuelo-Gómez, Á.; García-Azorín, D.; Guerrero, Á.L.; de Luis-García, R.; Rodríguez, M.; Aja-Fernández, S. Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition. Brain Sci. 2020, 10, 711.

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