Search Results (39)

Purpose: Focal cortical dysplasia (FCD) is a common developmental malformation disease of the cerebral cortex. Although mounting evidence has suggested that FCD lesions have variable locations and topographies throughout the cortex, few studies have explored consistencies in structural connectivity among different lesion types. In this study, we analyzed microscopic structural changes via lesion analysis and explored structural changes in nonlesion regions across the brain. Methods: Diffusion tensor imaging (DTI) and magnetization transfer imaging were used to compare FCD lesions and contralateral normal appearing gray/white matter (cNAG/WM). Voxel-based morphometry was calculated for 28 children with FCD and 34 sex- and age-matched healthy participants. DTI indices of the FCD and healthy control groups were analyzed via the tract-based spatial statistic method to evaluate the microstructure abnormalities of WM fiber tracts in individuals with FCD. Results: In terms of FCD lesions, compared with those of the cNAG, the fractional anisotropy (FA) values were decreased, and the mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values were increased; the magnetization transfer ratios were also decreased. In terms of whole-brain changes due to FCD, compared with the healthy control group, the FCD group showed a decrease in the volume of the right hippocampus and left anterior cingulate cortex. FCD patients had lower FA values, higher MD values, lower AD values, and mainly increased RD values in relation to WM microstructure. Conclusions: Microstructural abnormalities outside lesion regions may be related to injury to the epileptic network, and the identification of such abnormalities may complement diagnoses of FCD in pediatric patients. Full article

Zoning policies play a critical role in shaping the geography of urban and suburban development in the United States. Using data from the National Zoning and Land-Use Database and tract-level census data from 42 Metropolitan Statistical Areas, we classify metros into four zoning regime types based on the relative restrictiveness of urban and suburban land-use policies and compare trends in population growth and neighborhood change across these regimes. Our findings show that suburban areas have outpaced urban cores in population growth across all zoning configurations, with the most pronounced growth occurring in metros where restrictive urban zoning coexists with permissive suburban regulation. This growth is disproportionately concentrated in affluent suburban neighborhoods, suggesting a spatial sorting of access to resources and amenities. We also find that urban–suburban gentrification gaps are the smallest in these asymmetrical zoning regimes, suggesting that permissive suburban land use may facilitate spillover effects from constrained cores. These findings suggest that zoning asymmetries shape not only the geography of growth but also the spatial dynamics of gentrification. We argue for a metropolitan perspective on land-use governance to better understand the interconnected nature of suburbanization and the spatial expansion of gentrification. Full article

This study examines access to rental housing in the metropolitan area of Las Palmas de Gran Canaria, linking it to socio-economic inequalities and the increasing precarization. In recent years, housing affordability has worsened due to rising rents, stagnant wages, and speculative dynamics—particularly those linked to tourism and platform-based economies. Drawing on official data from the State Reference System for Rental Housing Prices (SERPAVI) and income statistics at the census tract level, this research quantifies housing affordability and spatial disparities through indicators such as economic effort rates. The analysis identifies patterns of exclusion and urban fragmentation, showing that large sectors of the population—especially those earning the minimum age—face severe barriers to accessing adequate housing. The findings highlight the insufficiency of current public policies and propose the expansion of social rental housing and stricter rental market regulation as necessary steps to ensure fairer urban conditions. Full article

Background/Objectives: Cerebral palsy (CP), often caused by early brain injury such as perinatal stroke or hemorrhage, is the most common lifelong motor disability. Early identification of at-risk infants and timely access to rehabilitation interventions are essential for improving long-term outcomes. The General Movements Assessment (GMA), performed in the first months of life, has high sensitivity and specificity to predict CP; however, the neurological correlates of general movements remain unclear. This analysis aimed to investigate the relationship between white matter integrity and general movements in infants with perinatal brain injury using advanced neuroimaging techniques. Methods: Diffusion-weighted MRI data were analyzed in 17 infants, 12 with perinatal brain injury and 5 typically developing infants. Tractography was used to identify the corticospinal tract, a key motor pathway often affected by perinatal brain injury, and tract-based spatial statistics (TBSS) were used to examine broader white matter networks. Diffusion parameters from the diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) models were compared between infants with and without typical general movements. Results: Corticospinal tract integrity did not differ between groups when averaged across hemispheres. However, infants with asymmetric general movements exhibited greater corticospinal tract asymmetries. A subset of infants with atypical general movement trajectories at <6 weeks and 3–5 months of age showed reduced corticospinal tract integrity compared to those with typical general movements. TBSS revealed significant differences in white matter integrity between infants with typical and atypical general movements in several white matter pathways, including the corpus callosum, the right posterior corona radiata, bilateral posterior thalamic radiations, the left fornix/stria terminalis, and bilateral tapetum. Conclusions: These findings support and expand upon previous research suggesting that white matter integrity across multiple brain regions plays a role in the formation of general movements. Corticospinal integrity alone was not strongly associated with general movements; interhemispheric and cortical-subcortical connectivity appear critical. These findings underscore the need for further research in larger, diverse populations to refine early biomarkers of neurodevelopmental impairment and guide targeted interventions. Full article

Background/Objectives: Parkinson’s disease (PD) is characterized by progressive neurodegeneration affecting both motor and non-motor functions. Identifying early alterations in PD patients before the onset of dopaminergic therapy is crucial for understanding disease progression and developing targeted interventions. This study aimed to investigate early changes in the putamen and thalamus in de novo PD patients using diffusion tensor imaging (DTI) compared to healthy controls. Methods: Thirty-one de novo PD patients and thirty-three healthy controls underwent DTI scanning. Tract-based spatial statistics were used to compare fractional anisotropy (FA) values between groups. Results: De novo PD patients exhibited significantly lower FA values in the right thalamus compared to controls, suggesting alterations in neuronal integrity or fiber degeneration in the early stages of the disease. However, no significant differences were demonstrated for FA values in the putamen between groups. Conclusions: We demonstrated that the FA value in the right thalamus was lower in PD compared with healthy controls. These findings highlight the potential of DTI as a non-invasive tool for detecting early neural changes in PD patients. Further studies would be helpful to assess the clinical utility of serial FA measurements of the subcortical gray matter in objective quantification of disease progression and monitoring of the therapeutic response. Full article

Background/Objectives: Recent studies indicate extensive shared white matter (WM) abnormalities between bipolar disorder (BD) and schizophrenia (SZ). However, the heterogeneity of WM in BD in terms of the presence of psychosis remains a critical issue for exploring the boundaries between BD and SZ. Previous studies comparing WM microstructures in psychotic and nonpsychotic BDs (PBD and NPBD) have resulted in limited findings, probably due to subtle changes, emphasizing the need for further investigation. Methods: Diffusion tensor imaging measures were obtained from 8 individuals with PBD, 8 with NPBD, and 22 healthy controls (HC), matched for age, gender, handedness, and educational years. Group comparisons were conducted using tract-based spatial statistics (TBSS). The most significant voxels showing differences between PBD and HC in the TBSS analyses were defined as a TBSS-ROI and subsequently analyzed. Results: Increased radial diffusivity (RD) in PBD compared to NPBD (p < 0.006; d = 1.706) was observed in TBSS-ROI, distributed in the confined regions of some WM tracts, including the body of the corpus callosum (bCC), the left genu of the CC (gCC), and the anterior and superior corona radiata (ACR and SCR). Additionally, NPBD exhibited significant age-associated RD increases (R² = 0.822, p < 0.001), whereas the greater RD observed in PBD compared to NPBD remained consistent across middle age. Conclusions: Preliminary findings from this small sample suggest severe frontal WM disconnection in the anterior interhemispheric communication, left fronto-limbic circuits, and cortico-striatal-thalamic loop in PBD compared to NPBD. While these results require replication and validation in larger and controlled samples, they provide insights into the pathophysiology of PBD, which is diagnostically located at the boundary between BD and SZ. Full article

A fairly large number of area-based indices have been developed in the United States (US) and other countries to examine the contextual effect of neighborhood-level socioeconomic status (SES) on health. However, two conceptual and methodological review articles raised several concerns about a multivariate approach to the measurement of neighborhood-level SES. To untangle some of the conceptual and methodological concerns raised in those review articles, the purpose of this study was to illuminate a couple of common oversights masked by the lack of analytical transparency in neighborhoods and health research. Using the State of California and its seven Metropolitan Statistical Areas as the study areas, census-tract-level population estimates from the 2000 Census as well as the 2005–2009, 2010–2014, and 2015–2019 American Community Survey were obtained from the United States Census Bureau’s website for conducting a sequence of data analyses. The results of this study suggest that a multivariate approach to the measurement of neighborhood-level SES may be susceptible to the spatial size and spatial configuration of geographic areas and/or the population size and population structure of geographic areas. For these reasons, a few underlying sources of measurement uncertainty, which may undermine the generalizability of existing area-based indices and their measurement validity, are discussed in a general sense so as to be relevant for examining the contextual effect of neighborhood-level SES on health in the US and other countries. Full article

Background. Major aortopulmonary collateral arteries (MAPCAs) are rare remnants of pulmonary circulation embryological development usually associated with complex congenital anomalies of the right ventricular outflow tract and pulmonary arteries. Effective management requires surgical unifocalization of MAPCAs and native pulmonary arteries (NPAs). Traditional imaging may lack the spatial clarity needed for precise surgical planning. Aim. This study evaluated the feasibility of integrating three-dimensional (3D) printing and virtual reality (VR) into preoperative planning to improve surgical precision, team communication, and parental understanding. In a prospective cohort study, nine infants undergoing MAPCA unifocalization were included. Four patients underwent conventional imaging-based planning (control), while five were additionally assessed using VR and 3D-printed models (intervention). The outcomes measured included operative times, team confidence, collaboration, and parental satisfaction. Statistical analysis was performed using standard tests. Results. The intervention group had shorter operative and cardiopulmonary bypass times compared to the control group. Intraoperative complications were absent in the VR/3D group but occurred in the control group. Medical staff in the VR/3D group reported significantly improved understanding of anatomy, surgical preparedness, and team collaboration (p < 0.05). Parents also expressed higher satisfaction, with better comprehension of their child’s anatomy and surgical plan. Conclusions. VR and 3D printing enhanced preoperative planning, surgical precision, and communication, proving valuable for complex congenital heart surgery. These technologies offer promising potential to improve clinical outcomes and patient–family experiences, meriting further investigation in larger studies. Full article

Owning a home has become a distant, often unattainable dream for many Americans since the 2007–2009 recession. The shortage of homes has decreased affordability, forcing 43 million U.S. households to become renters rather than owners. Racially targeted policies and widespread discrimination, coupled with neoliberal urban renewal policies, have forced communities of color, especially immigrants and the foreign-born, at the greatest disadvantage in homeownership. This paper examines tract-scale disparities in homeownership across major racial/ethnic groups. Using the U.S. Census Office of Management and Budget’s (OMB) 2019 definition of the 13-county-metropolitan statistical area (MSA) of Nashville, Tennessee, as the study area, I use five-year American Community Survey (ACS) (2015–2019) data estimates to examine the spatial disparity in homeownership and its predictors. Nashville MSA is one of the fastest-growing southern gateways, and it is also the largest, most diverse, and most intermixed metropolis in Tennessee. It contains higher than the state’s overall share of foreign-born, and during 2019–2040, its share of immigrants is projected to grow by 40.7%, making it the best-suited laboratory for race/immigrant-focused research on housing. This analysis finds significant differences in race-based mean per-capita income, with Whites ($32,522) and Asians ($32,556) at the top, whereas Blacks ($25,062) and Hispanics ($20,091) are at the lowest. The ratio of race-based per-capita-income-versus-median housing values is the highest for Whites (15.19) and Asians (15.07) and the lowest for Blacks (11.49) and Hispanics (9.27), putting these two groups as the most disadvantaged regarding their affordability. Regression models suggest lower White homeownership in higher diversity tracts among foreign-born-not-citizens (FBNCs), whereas Black and Hispanic homeownerships are higher in tracts with higher diversity among FBNCs. Interestingly, Asian homeownership is high in tracts with high-income Black tracts, pointing toward the increasing significance of class. Full article

Background: Lower urinary tract (LUT) symptoms are reported in more than 80% of patients with multiple sclerosis (MS), most commonly an overactive bladder (OAB). The relationship between brain white matter (WM) changes in MS and OAB symptoms is poorly understood. Objectives: We aim to evaluate (i) microstructural WM differences across MS patients (pwMS) with OAB symptoms, patients without LUT symptoms, and healthy subjects using diffusion tensor imaging (DTI), and (ii) associations between clinical OAB symptom scores and DTI indices. Methods: Twenty-nine female pwMS [mean age (SD) 43.3 years (9.4)], including seventeen with OAB [mean age (SD) 46.1 years (8.6)] and nine without LUT symptoms [mean age (SD) 37.5 years (8.9)], and fourteen healthy controls (HCs) [mean age (SD) 48.5 years (20)] were scanned in a 3T MRI with a DTI protocol. Additionally, clinical scans were performed for WM lesion segmentation. Group differences in fractional anisotropy (FA) were evaluated using tract-based spatial statistics. The Urinary Symptom Profile questionnaire assessed OAB severity. Results: A statistically significant reduction in FA (p = 0.004) was identified in microstructural WM in pwMS, compared with HCs. An inverse correlation was found between FA in frontal and parietal WM lobes and OAB scores (p = 0.021) in pwMS. Areas of lower FA, although this did not reach statistical significance, were found in both frontal lobes and the rest of the non-dominant hemisphere in pwMS with OAB compared with pwMS without LUT symptoms (p = 0.072). Conclusions: This study identified that lesions affecting different WM tracts in MS can result in OAB symptoms and demonstrated the role of the WM in the neural control of LUT functions. By using DTI, the association between OAB symptom severity and WM changes were identified, adding knowledge to the current LUT working model. As MS is predominantly a WM disease, these findings suggest that regional WM involvement, including of the anterior corona radiata, anterior thalamic radiation, superior longitudinal fasciculus, and superior frontal-occipital fasciculus and a non-dominant prevalence in WM, can result in OAB symptoms. OAB symptoms in MS correlate with anisotropy changes in different white matter tracts as demonstrated by DTI. Structural impairment in WM tracts plays an important role in LUT symptoms in MS. Full article

Urban crime prevention remains a critical challenge intertwined with socioeconomic disparities. This study investigates the spatial nexus between urban deprivation and crime decline in Chicago from 2015 to 2022, addressing the question: How do changes in neighborhood deprivation relate to crime reduction patterns? Using comprehensive crime incident and census tract Area Deprivation Index (ADI) data, this study conducted exploratory spatial analysis, regression modeling, and local bivariate relationship analysis. The findings reveal persistent hotspots of concentrated deprivation on Chicago’s south and west sides, alongside a general citywide crime decline. However, the current research uncovered significant spatial heterogeneity in both deprivation patterns and crime reduction, challenging the achievement of equitable public safety outcomes. Surprisingly, while crime incidents in 2015 and 2022 significantly predicted crime change, ADI scores were not statistically significant predictors in our regression model. Local bivariate analysis exposed diverse relationships between ADI changes and crime rate changes across neighborhoods, with 72.2% of census tracts showing no statistically significant relationship. This underscores the complexity of urban crime dynamics and the importance of local context in understanding these patterns. Our research contributes a nuanced understanding of the intricate relationship between urban deprivation and crime patterns, providing valuable insights for policymakers, law enforcement agencies, and urban planners. These findings highlight the need for integrated, long-term strategies that address both crime prevention and socioeconomic disparities, ultimately fostering safer, more equitable urban environments and informing evidence-based interventions tailored to specific neighborhood contexts. Full article

Schizophrenia is associated with changes in white matter (WM) integrity and with reduced life expectancy, in part because of the cardiometabolic side effects of antipsychotics. Physical activity (PA) has emerged as a candidate lifestyle intervention that is safe and effective. The study aimed to assess how an adapted PA program delivered remotely by web (e-APA) improved WM integrity in patients with schizophrenia (SZPs) and healthy controls (HCs) and to evaluate associations among WM integrity, cardiorespiratory fitness, and symptom severity. This longitudinal study was conducted over 16 weeks with 31 participants (18 SZPs and 13 HCs). Diffusion tensor imaging and tract-based spatial statistics were employed to assess WM integrity. Cardiorespiratory fitness was measured by maximal oxygen uptake (VO₂max), and assessments for clinical symptoms included the Positive and Negative Syndrome Scale, Self-evaluation of Negative Symptoms and the Brief Negative Syndrome Scale (BNSS). Only the SZPs had significantly increased WM integrity after the e-APA program, with increased fractional anisotropy and decreased radial diffusivity in fasciculi involved in motor functions and language process. Furthermore, decreased negative symptoms assessed with BNSS were associated with greater WM integrity following the program. These findings suggest that e-APA may improve WM integrity abnormalities and support e-APA as a promising therapeutic strategy. Full article

Introduction: Despite evidence suggesting deleterious effects of cannabis and nicotine tobacco product (NTP) use on white matter integrity, there have been limited studies examining white matter integrity among users of both cannabis and nicotine. Further, updated white matter methodology provides opportunities to investigate use patterns on neurite orientation dispersion and density (NODDI) indices and subtle tissue changes related to the intra- and extra-neurite compartment. We aimed to investigate how cannabis and NTP use among adolescents and young adults interacts to impact the white matter integrity microstructure. Materials and Methods: A total of 221 participants between the ages of 16 and 22 completed the Customary Drinking and Drug Use Record (CDDR) to measure substance use, and underwent a magnetic resonance imaging (MRI) session. Participants were divided into NTP-control and NTP groupings and cannabis-control and cannabis groupings (≥26 NTP/cannabis uses in past 6 months). Tract-Based Spatial Statistics (TBSS) and two-way between-subjects ANOVA investigated the effects of NTP use group, cannabis use group, and their interaction on fractional anisotropy (FA) and NODDI indices while controlling for age and biological sex. Results: NTP use was associated with decreased FA values and increased orientation dispersion in the left anterior capsule. There were no significant effects of cannabis use or the interaction of NTP and cannabis use on white matter outcomes. Discussion: NTP use was associated with altered white matter integrity in an adolescent and young adult sample. Findings suggest that NTP-associated alterations may be linked to altered fiber tract geometry and dispersed neurite structures versus myelination, as well as differential effects of NTP and cannabis use on white matter structure. Future work is needed to investigate how altered white matter is related to downstream behavioral effects from NTP use. Full article

This paper adapts an existing techno–social agent-based model (ABM) in order to develop a new framework for spatially validating ABMs. The ABM simulates citizen opposition to locally unwanted land uses, using historical data from an energy infrastructure siting process in Southern California. Spatial theory, as well as the model’s design, suggest that adequate validation requires multiple tests rather than relying solely on a single test-statistic. A pattern-oriented modeling approach was employed that first mapped real and simulated citizen comments across the US Census tract. The suite of spatial tests included Global Moran’s I, complemented with bivariate correlations, as well as the local indicators of spatial association (LISA) test. The global tests showed the model explained up to 65% of the variation in the historical data for US Census tract-level citizen comments on a locally unwanted land use. These global tests were also found helpful to inform the model’s calibration for the current application. The LISA results were even stronger, showing that the model predicted citizen comment clustering correctly in five of six Census tracts. It slightly over predicted comments further away from the land use. The LISA results and pattern-oriented modeling validation techniques identified theoretical factors to improve the modeling specification in future applications. The combined suite of validation techniques helped improve confidence in the model’s predictions. Full article

Previous studies have shown, in the United States (U.S.), that communities of color are exposed to significantly higher temperatures in urban environments than complementary White populations. Studies highlighting this disparity have generally been cross-sectional and are therefore “snapshots” in time. Using surface urban heat island (SUHI) intensity data, U.S. Census 2020 population counts, and a measure of residential segregation, this study performs a comparative analysis between census tracts identified as prevalent for White, Black, Hispanic and Asian populations and their thermal exposure from 2003 to 2018. The analysis concentrates on the top 200 most populous U.S. cities. SUHI intensity is shown to be increasing on average through time for the examined tracts. However, based on raw observations the increase is only statistically significant for White and Black prevalent census tracts. There is a 1.25 K to ~2.00 K higher degree of thermal exposure on average for communities of color relative to White prevalent areas. When examined on an inter-city basis, White and Black prevalent tracts had the largest disparity, as measured by SUHI intensity, in New Orleans, LA, by <6.00 K. Hispanic (>7.00 K) and Asian (<6.75 K) prevalent tracts were greatest in intensity in San Jose, CA. To further explore temporal patterns, two models were developed using a Bayesian hierarchical spatial temporal framework. One models the effect of varying the percentages of each population group relative to SUHI intensity within all examined tracts. Increases in percentages of Black, Hispanic, and Asian populations contributed to statistically significant increases in SUHI intensity. White increases in population percentage witnessed a lowering of SUHI intensity. Throughout all modeled tracts, there is a statistically significant 0.01 K per year average increase in SUHI intensity. A second model tests the effect of residential segregation on thermal inequity across all examined cities. Residential segregation, indeed, has a statistically significant positive association with SUHI intensity based on this portion of the analysis. Similarly, there is a statistically significant 0.01 K increase in average SUHI intensity per year for all cities. Results from this study can be used to guide and prioritize intervention strategies and further urgency related to social, climatic, and environmental justice concerns. Full article