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Open AccessArticle

Study of a Miniaturizable System for Optical Sensing Application to Human Cells

1
CNR-IMM Headquarters, Strada VIII Z.I. 5, 95121 Catania, Italy
2
Department of Biomedical and Biotechnological Sciences, Via S. Sofia 87, 95100 Catania, Italy
3
Department of Biological, Geological and Environmental Sciences, Univ. of Catania, 95124 Catania, Italy
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(5), 975; https://doi.org/10.3390/app9050975
Received: 20 February 2019 / Revised: 28 February 2019 / Accepted: 3 March 2019 / Published: 7 March 2019
(This article belongs to the Special Issue Nano-Biointerface for Biosensing)
Conventional approaches to human intracellular optical sensing, generally, require dedicated laboratories with bulky detection systems. They are performed by cell labeling procedures based on the use of fluorophores that are, mostly, phototoxic, invasive, bleached in case of prolonged light exposures, which require carriers and/or structural modifications for the cellular uptake. These issues, together with the sensitivity of the eukaryotic cell model, could be problematic towards the development of a robust sensing system suitable for biomedical screening. In this work, we studied a sensing system resulting from the combination of the commercial tris(2,2’bipyridyl)ruthenium(II) fluorophore, for cell labeling, with a potentially miniaturizable optical system composed by a laser source and a photomultiplier tube, for the fluorescence analysis. View Full-Text
Keywords: portable cell sensing system; human cell labeling; fluorophore; fluorescence detection; photomultiplier; confocal laser scanning microscopy portable cell sensing system; human cell labeling; fluorophore; fluorescence detection; photomultiplier; confocal laser scanning microscopy
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MDPI and ACS Style

Sciuto, E.L.; Villaggio, G.; Santangelo, M.F.; Laudani, S.; Federico, C.; Saccone, S.; Sinatra, F.; Libertino, S. Study of a Miniaturizable System for Optical Sensing Application to Human Cells. Appl. Sci. 2019, 9, 975. https://doi.org/10.3390/app9050975

AMA Style

Sciuto EL, Villaggio G, Santangelo MF, Laudani S, Federico C, Saccone S, Sinatra F, Libertino S. Study of a Miniaturizable System for Optical Sensing Application to Human Cells. Applied Sciences. 2019; 9(5):975. https://doi.org/10.3390/app9050975

Chicago/Turabian Style

Sciuto, Emanuele L.; Villaggio, Giusy; Santangelo, Maria F.; Laudani, Samuele; Federico, Concetta; Saccone, Salvatore; Sinatra, Fulvia; Libertino, Sebania. 2019. "Study of a Miniaturizable System for Optical Sensing Application to Human Cells" Appl. Sci. 9, no. 5: 975. https://doi.org/10.3390/app9050975

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