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Open AccessArticle

In Vivo Rat Brain Imaging through Full-Field Optical Coherence Microscopy Using an Ultrathin Short Multimode Fiber Probe

1
Graduate School of Science and Engineering, Yamagata University, Yonezawa, Yamagata 992-8510, Japan
2
Graduate School of Bio-Applications & Systems Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(2), 216; https://doi.org/10.3390/app9020216
Received: 17 November 2018 / Revised: 28 December 2018 / Accepted: 3 January 2019 / Published: 9 January 2019
(This article belongs to the Special Issue Optical Coherence Tomography and its Applications)
We demonstrate full-field optical coherence microscopy (OCM) using an ultrathin forward-imaging short multimode fiber (SMMF) probe with a core diameter of 50 μm, outer diameter of 125 μm, and length of 7.4 mm, which is a typical graded-index multimode fiber used for optical communications. The axial and lateral resolutions were measured to be 2.14 μm and 2.3 μm, respectively. By inserting the SMMF 4 mm into the cortex of an in vivo rat brain, scanning was performed to a depth of 147 μm from the SMMF facet with a field of view of 47 μm. Three-dimensional (3D) OCM images were obtained at depths ranging from approximately 20 μm to 90 μm. Based on the morphological information of the resliced 3D images and the dependence of the integration of the OCM image signal on the insertion length, the obtained 3D information of nerve fibers has been presented. View Full-Text
Keywords: full-field optical coherence microscopy; endoscopic imaging; medical optics instrumentation; fiber optics imaging full-field optical coherence microscopy; endoscopic imaging; medical optics instrumentation; fiber optics imaging
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Sato, M.; Eto, K.; Masuta, J.; Inoue, K.; Kurotani, R.; Abe, H.; Nishidate, I. In Vivo Rat Brain Imaging through Full-Field Optical Coherence Microscopy Using an Ultrathin Short Multimode Fiber Probe. Appl. Sci. 2019, 9, 216.

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