Next Article in Journal
Thickness Dependence of Switching Behavior in Ferroelectric BiFeO3 Thin Films: A Phase-Field Simulation
Next Article in Special Issue
Effect of HCV Core Antigen and RNA Clearance during Therapy with Direct Acting Antivirals on Hepatic Stiffness Measured with Shear Wave Elastography in Patients with Chronic Viral Hepatitis C
Previous Article in Journal
Numerical Characterisation of Active Drag and Lift Control for a Circular Cylinder in Cross-Flow
Previous Article in Special Issue
Shear Wave Elastography Combining with Conventional Grey Scale Ultrasound Improves the Diagnostic Accuracy in Differentiating Benign and Malignant Thyroid Nodules
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle

Interpretation US Elastography in Chronic Hepatitis B with or without Anti-HBV Therapy

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taipei 105, Taiwan
Department of Medical imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Department of Medical imaging and Radiological Sciences, College of Medicine, Institute for Radiological Research, Chang Gung University, Taoyuan 333, Taiwan
Division of Molecular and Genomic Medicine, National Health Research Institute, Taipei 115, Taiwan
Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Department of Liver and Transplantation Surgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Author to whom correspondence should be addressed.
Appl. Sci. 2017, 7(11), 1164;
Received: 15 September 2017 / Revised: 29 October 2017 / Accepted: 30 October 2017 / Published: 13 November 2017
(This article belongs to the Special Issue Ultrasound Elastography)
PDF [1155 KB, uploaded 14 November 2017]


Inflammation has significant impacts on liver fibrosis measurement by ultrasound elastography. The interpretation requires further optimization in patients with or without anti-viral therapy. We prospectively enrolled a consecutive series of patients with chronic hepatitis B who received liver histology analysis and acoustic radiation force impulse (ARFI). 146 patients who underwent liver biopsy (50.9%) or tumor resection (49.1%) were enrolled. 34 patients (23.3%) had been receiving anti-hepatitis B therapy of various duration. The areas under the receiver-operating characteristic (AUROC) for the diagnosis of Metavir F4 by mean ARFI was 0.820 in the non-treatment group and 0.796 in the treatment group. The ARFI tended to be not lower (100%) than the corresponding Metavir grading in patients with treatment within 12 months, equal (75%) from 13 to 31 months, and lower (71.4%) after 32 months. We conclude that ARFI is a reliable tool for measurement of liver fibrosis in chronic hepatitis B patients with ALT (alanine aminotransferase) <5x the upper limit of normal. For those patients under anti-HBV therapy, the optimal timing for ARFI analysis will be over 1–2.5 years of nucleos(t)ide analogue therapy. The ARFI measurement after 2.5 years tends to be lower than the corresponding histology grading. View Full-Text
Keywords: acoustic radiation force impulse; chronic hepatitis B; liver cirrhosis; anti-HBV therapy acoustic radiation force impulse; chronic hepatitis B; liver cirrhosis; anti-HBV therapy

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Lee, C.-H.; Wan, Y.-L.; Hsu, T.-H.; Huang, S.-F.; Yu, M.-C.; Lee, W.-C.; Tsui, P.-H.; Chen, Y.-C.; Lin, C.-Y.; Tai, D.-I. Interpretation US Elastography in Chronic Hepatitis B with or without Anti-HBV Therapy. Appl. Sci. 2017, 7, 1164.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Appl. Sci. EISSN 2076-3417 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top