Appl. Sci. 2015, 5(4), 910-925; https://doi.org/10.3390/app5040910
Double Properties of Novel Acylhydrazone Nanomaterials Based on a Conjugated System: Anion Binding Ability and Antibacterial Activity
1
Department of Chemistry, Xinxiang Medical University, Xinxiang 453003, Henan, China
2
Department of Immunity, Xinxiang Medical University, Xinxiang 453003, Henan, China
3
School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan, China
4
Department of Chemistry, Nankai University, Tianjin 300071, China
*
Author to whom correspondence should be addressed.
Academic Editor: Philippe Lambin
Received: 15 August 2015 / Revised: 28 September 2015 / Accepted: 12 October 2015 / Published: 21 October 2015
(This article belongs to the Section Nanotechnology and Applied Nanosciences)
Abstract
A series of new compounds (1–12) containing 1,5-diaza-fluorenone, 1,10-phenanthroline-5,6-dione, ferrocene-1,1ʹ-dione, anthracene-9-carbaldehyde have been synthesized and optimized. The nanomaterials were also developed successfully. The binding properties were evaluated for biologically important anions (F−, Cl−, Br−, I−, AcO−, and H2PO4−) by theoretical investigation, UV-vis, and fluorescence experiments, and compound 6 displayed the strongest binding ability for AcO− ion among the synthesized compounds. Theoretical investigation analysis revealed that the intramolecular hydrogen bond existed in the structure of compound 6 and the roles of molecular frontier orbitals in molecular interplay. In addition, compound 6 showed wide antibacterial activity for colon bacillus, typhoid bacillus, and Pseudomonas aeruginosa, and inferior activity for hay bacillus and Staphylococcus aureus. This series of acylhydrazone nanomaterials showed double properties, anion binding ability, and antibacterial activity. View Full-TextKeywords:
binding ability; antibacterial activity; acylhydrazone derivative; nanomaterials; synthesis
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Shang, X.; Li, W.; Feng, Y.; Li, X.; Xu, X. Double Properties of Novel Acylhydrazone Nanomaterials Based on a Conjugated System: Anion Binding Ability and Antibacterial Activity. Appl. Sci. 2015, 5, 910-925.
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