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Systematic Review

Summarizing Recent Developments on Autism Spectrum Disorder Detection and Classification Through Machine Learning and Deep Learning Techniques

Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64700, Mexico
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Authors to whom correspondence should be addressed.
Appl. Sci. 2025, 15(14), 8056; https://doi.org/10.3390/app15148056 (registering DOI)
Submission received: 22 April 2025 / Revised: 2 June 2025 / Accepted: 4 June 2025 / Published: 19 July 2025

Abstract

Autism Spectrum Disorder (ASD) encompasses various neurological disorders with symptoms varying by age, development, genetics, and other factors. Core symptoms include decreased pain sensitivity, difficulty sustaining eye contact, incorrect auditory responses, and social engagement issues. Diagnosing ASD poses challenges as signs can appear at early stages of life, leading to delayed diagnoses. Traditional diagnosis relies mainly on clinical observation, which is a subjective and time-consuming approach. However, AI-driven techniques, primarily those within machine learning and deep learning, are becoming increasingly prevalent for the efficient and objective detection and classification of ASD. In this work, we review and discuss the most relevant related literature between January 2016 and May 2024 by focusing on ASD detection or classification using diverse technologies, including magnetic resonance imaging, facial images, questionnaires, electroencephalogram, and eye tracking data. Our analysis encompasses works from major research repositories, including WoS, PubMed, Scopus, and IEEE. We discuss rehabilitation techniques, the structure of public and private datasets, and the challenges of automated ASD detection, classification, and therapy by highlighting emerging trends, gaps, and future research directions. Among the most interesting findings of this review are the relevance of questionnaires and genetics in the early detection of ASD, as well as the prevalence of datasets that are biased toward specific genders, ethnicities, or geographic locations, restricting their applicability. This document serves as a comprehensive resource for researchers, clinicians, and stakeholders, promoting a deeper understanding and advancement of AI applications in the evaluation and management of ASD.
Keywords: autism spectrum disorder (ASD); artificial intelligence (AI); bioinformatics; deep learning (DL); machine learning (ML) autism spectrum disorder (ASD); artificial intelligence (AI); bioinformatics; deep learning (DL); machine learning (ML)

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MDPI and ACS Style

Ahmed, M.; Hussain, S.; Ali, F.; Gárate-Escamilla, A.K.; Amaya, I.; Ochoa-Ruiz, G.; Ortiz-Bayliss, J.C. Summarizing Recent Developments on Autism Spectrum Disorder Detection and Classification Through Machine Learning and Deep Learning Techniques. Appl. Sci. 2025, 15, 8056. https://doi.org/10.3390/app15148056

AMA Style

Ahmed M, Hussain S, Ali F, Gárate-Escamilla AK, Amaya I, Ochoa-Ruiz G, Ortiz-Bayliss JC. Summarizing Recent Developments on Autism Spectrum Disorder Detection and Classification Through Machine Learning and Deep Learning Techniques. Applied Sciences. 2025; 15(14):8056. https://doi.org/10.3390/app15148056

Chicago/Turabian Style

Ahmed, Masroor, Sadam Hussain, Farman Ali, Anna Karen Gárate-Escamilla, Ivan Amaya, Gilberto Ochoa-Ruiz, and José Carlos Ortiz-Bayliss. 2025. "Summarizing Recent Developments on Autism Spectrum Disorder Detection and Classification Through Machine Learning and Deep Learning Techniques" Applied Sciences 15, no. 14: 8056. https://doi.org/10.3390/app15148056

APA Style

Ahmed, M., Hussain, S., Ali, F., Gárate-Escamilla, A. K., Amaya, I., Ochoa-Ruiz, G., & Ortiz-Bayliss, J. C. (2025). Summarizing Recent Developments on Autism Spectrum Disorder Detection and Classification Through Machine Learning and Deep Learning Techniques. Applied Sciences, 15(14), 8056. https://doi.org/10.3390/app15148056

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