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Open AccessArticle

Depression and Microbiome—Study on the Relation and Contiguity between Dogs and Humans

Department of Veterinary Medical Science, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, Italy
Department of Agricultural and Food Sciences, University of Bologna, Via del Florio 2, 40064 Ozzano Emilia, Italy
Department of Physics and Astronomy, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy
Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(2), 573;
Received: 22 November 2019 / Revised: 23 December 2019 / Accepted: 7 January 2020 / Published: 13 January 2020
Behavioral studies demonstrate that not only humans, but all other animals including dogs, can suffer from depression. A quantitative molecular evaluation of fatty acids in human and animal platelets has already evidenced similarities between people suffering from depression and German Shepherds, suggesting that domestication has led dogs to be similar to humans. In order to verify whether humans and dogs suffering from similar pathologies also share similar microorganisms at the intestinal level, in this study the gut-microbiota composition of 12 German Shepherds was compared to that of 15 dogs belonging to mixed breeds which do not suffer from depression. Moreover, the relation between the microbiota of the German Shepherd’s group and that of patients with depression has been investigated. The results indicate that the German Shepherd’s gut-microbiota has a different composition compared to other dog breeds and is characterized by microbial groups identified in humans with depression, highlighting the existence of a “core” microbiota associated with depression. View Full-Text
Keywords: gut-microbiota-brain axis; dog depression; human depression; microbiome gut-microbiota-brain axis; dog depression; human depression; microbiome
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Mondo, E.; De Cesare, A.; Manfreda, G.; Sala, C.; Cascio, G.; Accorsi, P.A.; Marliani, G.; Cocchi, M. Depression and Microbiome—Study on the Relation and Contiguity between Dogs and Humans. Appl. Sci. 2020, 10, 573.

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