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Article

Pharmacological and Cosmeceutical Potential of Seaweed Beach-Casts of Macaronesia

1
Canary Islands Cancer Research Institute Foundation (FICIC), Ave. La Trinidad 61, Torre A. Arévalo, 7th floor, 38204 La Laguna, Spain
2
Instituto Tecnológico de Canarias, Playa de Pozo Izquierdo s/n, 35119 Santa Lucía, Spain
3
ISOPlexis—Centre in Sustainable Agriculture and Food Technology and Faculty of Life Sciences, University of Madeira, Campus da Penteada, 9020-105 Funchal, Portugal
4
cE3c–Centre for Ecology, Evolution and Environmental Changes/Azorean Biodiversity Group and Faculty of Sciences and Technology, University of Azores, 9500-321 Ponta Delgada, Portugal
5
LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2020, 10(17), 5831; https://doi.org/10.3390/app10175831
Received: 20 July 2020 / Revised: 18 August 2020 / Accepted: 21 August 2020 / Published: 23 August 2020
(This article belongs to the Special Issue Algae as a Nutritional and Bioactive Biomass)
Seaweed beach-casts are a seasonal phenomenon that regularly deposits tons of algae biomass on beaches, which are usually disposed of in landfills. The present work aimed to contribute to the valorization of this biomass by studying bioactivities that reveal its potential in the pharmaceutical and/or cosmeceutical industries. Methanol and ethanol extracts and fractions from 15 beach-casts biomass were tested for a range of bioactivities. Eight of the most active samples exhibit IC50 values between 11.38 µg/mL and 19.28 µg/mL and selectivity indexes higher than 3.8, against NCI-H1299 (lung cancer) and T47D (breast cancer). Concerning antiaging potential, all the extracts tested presented UV protection, with SPF values above 30, like the standard sunscreen. Regarding aging-related enzymes, 24 samples were tyrosinase inhibitors exhibiting IC50 values from 9.01 µg/mL to 200.09 µg/mL. Eight extracts inhibited collagenase (IC50 < 248.76 µg/mL), two of them more actively than positive control EDTA (IC50 = 59.26 µg/mL). In addition to UV protection, the cumulative effect of antityrosinase and anticollagenase activities shown by the samples suggest that they may play a significant role in preventing skin photoaging. The results obtained demonstrate the high potential of beach-cast seaweed biomass as sources of cosmetic bioproducts with antiaging effects, and of selective cytotoxic metabolites. View Full-Text
Keywords: beach-cast seaweeds; biomass valorization; anticancer; antiaging; antityrosinase; UV protection beach-cast seaweeds; biomass valorization; anticancer; antiaging; antityrosinase; UV protection
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MDPI and ACS Style

Zárate, R.; Portillo, E.; Teixidó, S.; Carvalho, M.A.A.P.d.; Nunes, N.; Ferraz, S.; Seca, A.M.L.; Rosa, G.P.; Barreto, M.C. Pharmacological and Cosmeceutical Potential of Seaweed Beach-Casts of Macaronesia. Appl. Sci. 2020, 10, 5831. https://doi.org/10.3390/app10175831

AMA Style

Zárate R, Portillo E, Teixidó S, Carvalho MAAPd, Nunes N, Ferraz S, Seca AML, Rosa GP, Barreto MC. Pharmacological and Cosmeceutical Potential of Seaweed Beach-Casts of Macaronesia. Applied Sciences. 2020; 10(17):5831. https://doi.org/10.3390/app10175831

Chicago/Turabian Style

Zárate, Rafael; Portillo, Eduardo; Teixidó, Sílvia; Carvalho, Miguel A.A.P.d.; Nunes, Nuno; Ferraz, Sónia; Seca, Ana M.L.; Rosa, Gonçalo P.; Barreto, Maria C. 2020. "Pharmacological and Cosmeceutical Potential of Seaweed Beach-Casts of Macaronesia" Appl. Sci. 10, no. 17: 5831. https://doi.org/10.3390/app10175831

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