Table of Contents
Med. Sci., Volume 7, Issue 7 (July 2019)
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Cover Story (view full-size image) Epidemiological studies suggest that elevated intrauterine androgen levels increase the [...] Read more. Epidemiological studies suggest that elevated intrauterine androgen levels increase the susceptibility of the female offspring to develop the polycystic ovary syndrome (PCOS) phenotype. Our longitudinal studies in female sheep demonstrate that prenatal testosterone excess disrupts both the reproductive and the metabolic systems, leading to a self-perpetuating vicious cycle with defects in one system, impacting the other. These findings in the sheep model suggest that interventions targeting multiple organ systems may be required to prevent or ameliorate the progression of developmentally programmed disorders, such as PCOS. While prenatal interventions have the potential to prevent the development of disease, postnatal interventions are aimed at ameliorating disease manifestation. View this paper.