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Med. Sci., Volume 7, Issue 8 (August 2019)
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Cover Story (view full-size image) This review will highlight the insights gained into the neuroendocrine mechanisms underlying PCOS, [...] Read more. This review will highlight the insights gained into the neuroendocrine mechanisms underlying PCOS, focusing primarily on data gleaned from preclinical animal models of PCOS. First, we will briefly introduce the various PCOS animal models and summarize their neuroendocrine reproductive traits, focusing on gonadotropin and sex steroid levels. Following that, we will review recent findings on brain and neuroendocrine alterations at the cellular, molecular, and physiological levels, in various PCOS research models, and discuss how this may relate to the human PCOS condition. View this paper