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Steroid Mass Spectrometry for the Diagnosis of PCOS

Biochemistry Dept, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Southmoor Rd, Manchester, M23 9LT, UK
Med. Sci. 2019, 7(7), 78; https://doi.org/10.3390/medsci7070078
Received: 12 June 2019 / Revised: 8 July 2019 / Accepted: 9 July 2019 / Published: 10 July 2019
(This article belongs to the Special Issue Polycystic Ovary Syndrome)
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PDF [218 KB, uploaded 18 July 2019]

Abstract

The most appropriate steroids to measure for the diagnosis of hyperandrogenism in polycystic ovary syndrome (PCOS) are still open to debate but should preferably be measured using a high-quality method such as liquid chromatography tandem mass spectrometry (LC-MS/MS). Measurement of testosterone is recommended in all of the current clinical guidelines but other steroids, such as androstenedione and dehydroepiandrosterone sulfate (DHEAS), have also been shown to be useful in diagnosing PCOS and may give additional information on metabolic risk. The 11-oxygenated steroids, and in particular 11KT derived mainly from the adrenal gland, are also increasing in prominence and have been shown to be the dominant androgens in this condition. Polycystic ovary syndrome is a complex syndrome and it is not surprising that each of the clinical phenotypes are associated with different patterns of steroid hormones; it is likely that steroid profiling with LC-MS/MS may be better at identifying hyperandrogensim in each of these phenotypes. Research into PCOS has been hampered by the small sample size of clinical studies previously undertaken and larger studies, preferably using LC-MS/MS profiling of steroids, are needed View Full-Text
Keywords: androgens; polycystic ovary syndrome (PCOS); liquid chromatography tandem mass spectrometry (LC-MS/MS); testosterone; 11-ketotestosterone androgens; polycystic ovary syndrome (PCOS); liquid chromatography tandem mass spectrometry (LC-MS/MS); testosterone; 11-ketotestosterone
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Keevil, B. Steroid Mass Spectrometry for the Diagnosis of PCOS. Med. Sci. 2019, 7, 78.

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