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Med. Sci. 2018, 6(3), 70; https://doi.org/10.3390/medsci6030070

Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit

Department of Genetics and Bioengineering, Yeditepe University, 34755 Istanbul, Turkey
Received: 27 July 2018 / Revised: 20 August 2018 / Accepted: 27 August 2018 / Published: 30 August 2018
(This article belongs to the Special Issue Transglutaminases in Health and Disease)
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Abstract

A search for the “magic bullet”, a molecule, the targeting abilities of which could stop the migration of tumor cells, is currently underway, but remains in the early stages. There are still many unknowns regarding the cell migration. The main approach is the employment of mouse models, that are sources of valuable information, but still cannot answer all of the questions. One of the molecules of interest is Transglutaminase 2 (TG2). It is a well-described molecule involved in numerous pathways and elevated in metastatic tumors. The question remains whether mice and humans can give the same answer considering TG2. View Full-Text
Keywords: tumor cell migration; TG2; mouse models tumor cell migration; TG2; mouse models
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Bihorac, A. Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit. Med. Sci. 2018, 6, 70.

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