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The Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease

1
Department of Inflammation & Immunity, M17, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
2
Department of Pediatric Gastroenterology, M17, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
3
Director for Nutrition Research Center for Human Nutrition, M17, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
*
Author to whom correspondence should be addressed.
Med. Sci. 2018, 6(2), 47; https://doi.org/10.3390/medsci6020047
Received: 30 April 2018 / Revised: 18 May 2018 / Accepted: 26 May 2018 / Published: 5 June 2018
(This article belongs to the Special Issue Therapeutic Potential of the Microbiome)
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with prevalence increasing in parallel with the rising incidence in obesity. Believed to be a “multiple-hit” disease, several factors contribute to NAFLD initiation and progression. Of these, the gut microbiome is gaining interest as a significant factor in NAFLD prevalence. In this paper, we provide an in-depth review of the progression of NAFLD, discussing the mechanistic modes of hepatocyte injury and the potential role for manipulation of the gut microbiome as a therapeutic strategy in the prevention and treatment of NAFLD. View Full-Text
Keywords: gut microbiome; NAFLD; probiotics; apoptosis; necroptosis gut microbiome; NAFLD; probiotics; apoptosis; necroptosis
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Roychowdhury, S.; Selvakumar, P.C.; Cresci, G.A. The Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease. Med. Sci. 2018, 6, 47.

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