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Med. Sci. 2018, 6(2), 47; https://doi.org/10.3390/medsci6020047

The Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease

1
Department of Inflammation & Immunity, M17, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
2
Department of Pediatric Gastroenterology, M17, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
3
Director for Nutrition Research Center for Human Nutrition, M17, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
*
Author to whom correspondence should be addressed.
Received: 30 April 2018 / Revised: 18 May 2018 / Accepted: 26 May 2018 / Published: 5 June 2018
(This article belongs to the Special Issue Therapeutic Potential of the Microbiome)
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Abstract

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with prevalence increasing in parallel with the rising incidence in obesity. Believed to be a “multiple-hit” disease, several factors contribute to NAFLD initiation and progression. Of these, the gut microbiome is gaining interest as a significant factor in NAFLD prevalence. In this paper, we provide an in-depth review of the progression of NAFLD, discussing the mechanistic modes of hepatocyte injury and the potential role for manipulation of the gut microbiome as a therapeutic strategy in the prevention and treatment of NAFLD. View Full-Text
Keywords: gut microbiome; NAFLD; probiotics; apoptosis; necroptosis gut microbiome; NAFLD; probiotics; apoptosis; necroptosis
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Roychowdhury, S.; Selvakumar, P.C.; Cresci, G.A. The Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease. Med. Sci. 2018, 6, 47.

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