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Article

Cinnamon Extract and Probiotic Supplementation Alleviate Copper-Induced Nephrotoxicity via Modulating Oxidative Stress, Inflammation, and Apoptosis in Broiler Chickens

1
Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
2
Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agriculture Research Center, Dokki, Giza 12618, Egypt
3
Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Zagazig University, Al Sharqia Governorate 44519, Egypt
4
Department of Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
*
Author to whom correspondence should be addressed.
Academic Editor: Peter F. Surai
Animals 2021, 11(6), 1609; https://doi.org/10.3390/ani11061609
Received: 26 April 2021 / Revised: 20 May 2021 / Accepted: 26 May 2021 / Published: 29 May 2021
Copper (Cu), an essential trace element required for many biological processes inside the body, may cause deleterious effects on several body organs when its administration exceeds the tolerable upper intake level. Recently, great attention has been given to the use of natural compounds that are rich sources of biologically active molecules to prevent and treat many diseases. Therefore, this study was designed to explore the possible protective effects of cinnamon extract and probiotic against nephrotoxicity caused by overdose of Cu in broiler chickens. The whole experiment lasted 6 weeks. Cinnamon extract and probiotic showed remarkable antioxidant, anti-inflammatory, and antiapoptotic properties against the toxic effects of excess Cu in renal tissues of chickens. Based on our results, we conclude that cinnamon extract and/or probiotic can serve as an effective therapeutic option to decrease the renal injury caused by Cu poisoning in broiler chickens.
The present study aimed to assess the potential protective effects of cinnamon (Cinnamomum zeylanicum, Cin) and probiotic against CuSO4-induced nephrotoxicity in broiler chickens. One-day-old Cobb chicks were assigned into seven groups (15 birds/group): control group, fed basal diet; Cin group, fed the basal diet mixed with Cin (200 mg/kg); PR group, receiving PR (1 g/4 L water); Cu group, fed the basal diets mixed with CuSO4 (300 mg/kg); Cu + Cin group; Cu + PR group; and Cu + Cin + PR group. All treatments were given daily for 6 weeks. Treatment of Cu-intoxicated chickens with Cin and/or PR reduced (p < 0.05) Cu contents in renal tissues and serum levels of urea, creatinine, and uric acid compared to the Cu group. Moreover, Cin and PR treatment decreased lipid peroxidation and increased antioxidant enzyme activities in chickens’ kidney. Additionally, significant reduction (p < 0.05) in the mRNA expression of tumor necrosis factor alpha (TNF-α), interleukin (IL-2) and Bax, and in cyclooxygenase (COX-II) enzyme expression, and significant elevation (p < 0.05) in mRNA expression of IL-10 and Bcl-2 were observed in kidneys of Cu + Cin, Cu + PR, and Cu + Cin + PR groups compared to Cu group. Conclusively, Cin and/or PR afford considerable renal protection against Cu-induced nephrotoxicity in chickens. View Full-Text
Keywords: cinnamon; copper; probiotic; nephrotoxicity; oxidative stress; inflammation cinnamon; copper; probiotic; nephrotoxicity; oxidative stress; inflammation
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MDPI and ACS Style

Elazab, S.T.; Elshater, N.S.; Kishaway, A.T.Y.; EI-Emam, H.A. Cinnamon Extract and Probiotic Supplementation Alleviate Copper-Induced Nephrotoxicity via Modulating Oxidative Stress, Inflammation, and Apoptosis in Broiler Chickens. Animals 2021, 11, 1609. https://doi.org/10.3390/ani11061609

AMA Style

Elazab ST, Elshater NS, Kishaway ATY, EI-Emam HA. Cinnamon Extract and Probiotic Supplementation Alleviate Copper-Induced Nephrotoxicity via Modulating Oxidative Stress, Inflammation, and Apoptosis in Broiler Chickens. Animals. 2021; 11(6):1609. https://doi.org/10.3390/ani11061609

Chicago/Turabian Style

Elazab, Sara T., Nahla S. Elshater, Asmaa T.Y. Kishaway, and Huda A. EI-Emam. 2021. "Cinnamon Extract and Probiotic Supplementation Alleviate Copper-Induced Nephrotoxicity via Modulating Oxidative Stress, Inflammation, and Apoptosis in Broiler Chickens" Animals 11, no. 6: 1609. https://doi.org/10.3390/ani11061609

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