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Volume 9
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10.3390/microorganisms9061324
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Article

The Respiratory Commensal Bacterium Dolosigranulum pigrum 040417 Improves the Innate Immune Response to Streptococcus pneumoniae

by
Fernanda Raya Tonetti
1,†,
Mikado Tomokiyo
2,3,†,
Ramiro Ortiz Moyano
1,
Sandra Quilodrán-Vega
4,
Hikari Yamamuro
2,3,
Paulraj Kanmani
2,
Vyacheslav Melnikov
5,
Shoichiro Kurata
6,
Haruki Kitazawa
2,3,* and
Julio Villena
1,2,*
1
Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucumán 4000, Argentina
2
Food and Feed Immunology Group, Laboratory of Animal Food Function, Graduate School of Agricultural Science, Tohoku University, Sendai 980-8572, Japan
3
Livestock Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 980-8572, Japan
4
Laboratory of Food Microbiology, Faculty of Veterinary Sciences, University of Concepción, Chillán 3780000, Chile
5
Gabrichevsky Research Institute for Epidemiology and Microbiology, 125212 Moscow, Russia
6
Laboratory of Molecular Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan
*
Authors to whom correspondence should be addressed.
†
Contributed equally to this work.
Microorganisms 2021, 9(6), 1324; https://doi.org/10.3390/microorganisms9061324
Submission received: 22 May 2021 / Revised: 11 June 2021 / Accepted: 16 June 2021 / Published: 18 June 2021
(This article belongs to the Special Issue Probiotics for Next Generations)
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Abstract

Previously, we demonstrated that the nasal administration of Dolosigranulum pigrum 040417 differentially modulated the respiratory innate immune response triggered by the activation of Toll-like receptor 2 in infant mice. In this work, we aimed to evaluate the beneficial effects of D. pigrum 040417 in the context of Streptococcus pneumoniae infection and characterize the role of alveolar macrophages (AMs) in the immunomodulatory properties of this respiratory commensal bacterium. The nasal administration of D. pigrum 040417 to infant mice significantly increased their resistance to pneumococcal infection, differentially modulated respiratory cytokines production, and reduced lung injuries. These effects were associated to the ability of the 040417 strain to modulate AMs function. Depletion of AMs significantly reduced the capacity of the 040417 strain to improve both the reduction of pathogen loads and the protection against lung tissue damage. We also demonstrated that the immunomodulatory properties of D. pigrum are strain-specific, as D. pigrum 030918 was not able to modulate respiratory immunity or to increase the resistance of mice to an S. pneumoniae infection. These findings enhanced our knowledge regarding the immunological mechanisms involved in modulation of respiratory immunity induced by beneficial respiratory commensal bacteria and suggested that particular strains could be used as next-generation probiotics.
Keywords: respiratory commensal bacteria; upper respiratory tract; next-generation probiotics; Dolosigranulum pigrum; Streptococcus pneumoniae; alveolar macrophages respiratory commensal bacteria; upper respiratory tract; next-generation probiotics; Dolosigranulum pigrum; Streptococcus pneumoniae; alveolar macrophages

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MDPI and ACS Style

Raya Tonetti, F.; Tomokiyo, M.; Ortiz Moyano, R.; Quilodrán-Vega, S.; Yamamuro, H.; Kanmani, P.; Melnikov, V.; Kurata, S.; Kitazawa, H.; Villena, J. The Respiratory Commensal Bacterium Dolosigranulum pigrum 040417 Improves the Innate Immune Response to Streptococcus pneumoniae. Microorganisms 2021, 9, 1324. https://doi.org/10.3390/microorganisms9061324

AMA Style

Raya Tonetti F, Tomokiyo M, Ortiz Moyano R, Quilodrán-Vega S, Yamamuro H, Kanmani P, Melnikov V, Kurata S, Kitazawa H, Villena J. The Respiratory Commensal Bacterium Dolosigranulum pigrum 040417 Improves the Innate Immune Response to Streptococcus pneumoniae. Microorganisms. 2021; 9(6):1324. https://doi.org/10.3390/microorganisms9061324

Chicago/Turabian Style

Raya Tonetti, Fernanda, Mikado Tomokiyo, Ramiro Ortiz Moyano, Sandra Quilodrán-Vega, Hikari Yamamuro, Paulraj Kanmani, Vyacheslav Melnikov, Shoichiro Kurata, Haruki Kitazawa, and Julio Villena. 2021. "The Respiratory Commensal Bacterium Dolosigranulum pigrum 040417 Improves the Innate Immune Response to Streptococcus pneumoniae" Microorganisms 9, no. 6: 1324. https://doi.org/10.3390/microorganisms9061324

APA Style

Raya Tonetti, F., Tomokiyo, M., Ortiz Moyano, R., Quilodrán-Vega, S., Yamamuro, H., Kanmani, P., Melnikov, V., Kurata, S., Kitazawa, H., & Villena, J. (2021). The Respiratory Commensal Bacterium Dolosigranulum pigrum 040417 Improves the Innate Immune Response to Streptococcus pneumoniae. Microorganisms, 9(6), 1324. https://doi.org/10.3390/microorganisms9061324

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