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Article

Immune-modulatory Properties of the Octapeptide NAP in Campylobacter jejuni Infected Mice Suffering from Acute Enterocolitis

1
Institute of Microbiology, Infectious Diseases and Immunology, Charité-University Medicine Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany
2
Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Sagol School of Neuroscience and Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv 69978, Israel
*
Author to whom correspondence should be addressed.
Contributed equally.
Microorganisms 2020, 8(6), 802; https://doi.org/10.3390/microorganisms8060802
Received: 30 April 2020 / Revised: 22 May 2020 / Accepted: 24 May 2020 / Published: 26 May 2020
(This article belongs to the Special Issue Foodborne Pathogen Campylobacter)
Human infections with the food-borne zoonotic pathogen Campylobacter jejuni are progressively rising and constitute serious global public health and socioeconomic burdens. Hence, application of compounds with disease-alleviating properties are required to combat campylobacteriosis and post-infectious sequelae. In our preclinical intervention study applying an acute C. jejuni induced enterocolitis model, we surveyed the anti-pathogenic and immune-modulatory effects of the octapeptide NAP which is well-known for its neuroprotective and anti-inflammatory properties. Therefore, secondary abiotic IL-10−/− mice were perorally infected with C. jejuni and intraperitoneally treated with synthetic NAP from day 2 until day 5 post-infection. NAP-treatment did not affect gastrointestinal C. jejuni colonization but could alleviate clinical signs of infection that was accompanied by less pronounced apoptosis of colonic epithelial cells and enhancement of cell regenerative measures on day 6 post-infection. Moreover, NAP-treatment resulted in less distinct innate and adaptive pro-inflammatory immune responses that were not restricted to the intestinal tract but could also be observed in extra-intestinal and even systemic compartments. NAP-treatment further resulted in less frequent translocation of viable pathogens from the intestinal tract to extra-intestinal including systemic tissue sites. For the first time, we here provide evidence that NAP application constitutes a promising option to combat acute campylobacteriosis. View Full-Text
Keywords: NAP; activity-dependent neuroprotective protein (ADNP); anti-inflammatory effects; immune-modulatory properties; Campylobacter jejuni; acute campylobacteriosis model; host–pathogen interaction; gut–brain axis NAP; activity-dependent neuroprotective protein (ADNP); anti-inflammatory effects; immune-modulatory properties; Campylobacter jejuni; acute campylobacteriosis model; host–pathogen interaction; gut–brain axis
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MDPI and ACS Style

Heimesaat, M.M.; Mousavi, S.; Kløve, S.; Genger, C.; Weschka, D.; Giladi, E.; Bereswill, S.; Gozes, I. Immune-modulatory Properties of the Octapeptide NAP in Campylobacter jejuni Infected Mice Suffering from Acute Enterocolitis. Microorganisms 2020, 8, 802. https://doi.org/10.3390/microorganisms8060802

AMA Style

Heimesaat MM, Mousavi S, Kløve S, Genger C, Weschka D, Giladi E, Bereswill S, Gozes I. Immune-modulatory Properties of the Octapeptide NAP in Campylobacter jejuni Infected Mice Suffering from Acute Enterocolitis. Microorganisms. 2020; 8(6):802. https://doi.org/10.3390/microorganisms8060802

Chicago/Turabian Style

Heimesaat, Markus M., Soraya Mousavi, Sigri Kløve, Claudia Genger, Dennis Weschka, Eliezer Giladi, Stefan Bereswill, and Illana Gozes. 2020. "Immune-modulatory Properties of the Octapeptide NAP in Campylobacter jejuni Infected Mice Suffering from Acute Enterocolitis" Microorganisms 8, no. 6: 802. https://doi.org/10.3390/microorganisms8060802

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