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Open AccessArticle

Unveiling of Concealed Processes for the Degradation of Pharmaceutical Compounds by Neopestalotiopsis sp.

Department of Environmental Engineering, Yonsei University, Wonju 26493, Korea
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Microorganisms 2019, 7(8), 264; https://doi.org/10.3390/microorganisms7080264
Received: 30 July 2019 / Revised: 9 August 2019 / Accepted: 15 August 2019 / Published: 16 August 2019
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Abstract

The presence of pharmaceutical products has raised emerging biorisks in aquatic environments. Fungi have been considered in sustainable approaches for the degradation of pharmaceutical compounds from aquatic environments. Soft rot fungi of the Ascomycota phylum are the most widely distributed among fungi, but their ability to biodegrade pharmaceuticals has not been studied as much as that of white rot fungi of the Basidiomycota phylum. Herein, we evaluated the capacity of the soft rot fungus Neopestalotiopsis sp. B2B to degrade pharmaceuticals under treatment of woody and nonwoody lignocellulosic biomasses. Nonwoody rice straw induced laccase activity fivefold compared with that in YSM medium containing polysaccharide. But B2B preferentially degraded polysaccharide over lignin regions in woody sources, leading to high concentrations of sugar. Hence, intermediate products from saccharification may inhibit laccase activity and thereby halt the biodegradation of pharmaceutical compounds. These results provide fundamental insights into the unique characteristics of pharmaceutical degradation by soft rot fungus Neopestalotiopsis sp. in the presence of preferred substrates during delignification. View Full-Text
Keywords: Ascomycota; biodegradation; extracellular enzymes; Neopestalotiopsis; pharmaceutical compounds Ascomycota; biodegradation; extracellular enzymes; Neopestalotiopsis; pharmaceutical compounds
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Kang, B.R.; Kim, M.S.; Lee, T.K. Unveiling of Concealed Processes for the Degradation of Pharmaceutical Compounds by Neopestalotiopsis sp.. Microorganisms 2019, 7, 264.

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