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Microorganisms 2018, 6(4), 100; https://doi.org/10.3390/microorganisms6040100

Recent Advances in Shiga Toxin-Producing Escherichia coli Research in Latin America

1
Department of Microbiology and Immunology, Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA
2
Laboratorio de Fisiopatogenia, Departamento de Fisiología, Instituto de Fisiología y Biofísica Bernardo Houssay, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina
3
Laboratory of Genetic Engineering and Molecular Biology, Institute of Basic and Applied Microbiology, National University of Quilmes, Bernal, Buenos Aires 1876, Argentina
4
Instituto de Genética Veterinaria Ing. Fernando N. Dulout (UNLP-CONICET, La Plata), Facultad de Ciencias Veterinarias, La Plata 1900, Argentina
5
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Fisiología y Biofísica Houssay, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina
6
Centro de Investigación Veterinaria de Tandil (CONICET-CIC-UNCPBA), Facultad de Ciencias Veterinarias, Tandil 7000, Argentina
7
Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Received: 6 August 2018 / Revised: 1 September 2018 / Accepted: 28 September 2018 / Published: 28 September 2018
(This article belongs to the Special Issue Pathogenesis of Enterohaemorrhagic Escherichia coli)
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Abstract

Pathogenic Escherichia coli are known to be a common cause of diarrheal disease and a frequently occurring bacterial infection in children and adults in Latin America. Despite the effort to combat diarrheal infections, the south of the American continent remains a hot spot for infections and sequelae associated with the acquisition of one category of pathogenic E. coli, the Shiga toxin-producing E. coli (STEC). This review will focus on an overview of the prevalence of different STEC serotypes in human, animals and food products, focusing on recent reports from Latin America outlining the recent research progress achieved in this region to combat disease and endemicity in affected countries and to improve understanding on emerging serotypes and their virulence factors. Furthermore, this review will highlight the progress done in vaccine development and treatment and will also discuss the effort of the Latin American investigators to respond to the thread of STEC infections by establishing a multidisciplinary network of experts that are addressing STEC-associated animal, human and environmental health issues, while trying to reduce human disease. Regardless of the significant scientific contributions to understand and combat STEC infections worldwide, many significant challenges still exist and this review has focus in the Latin American efforts as an example of what can be accomplished when multiple groups have a common goal. View Full-Text
Keywords: Shiga toxin; STEC; Shiga toxin-producing E. coli; enterohemorrhagic E. coli; hemolytic uremic syndrome; diarrhea; vaccines; therapeutics; phages Shiga toxin; STEC; Shiga toxin-producing E. coli; enterohemorrhagic E. coli; hemolytic uremic syndrome; diarrhea; vaccines; therapeutics; phages
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Torres, A.G.; Amaral, M.M.; Bentancor, L.; Galli, L.; Goldstein, J.; Krüger, A.; Rojas-Lopez, M. Recent Advances in Shiga Toxin-Producing Escherichia coli Research in Latin America. Microorganisms 2018, 6, 100.

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