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New Genotypes of Coxiella burnetii Circulating in Brazil and Argentina

1
Departamento de Higiene Veterinária e Saúde Pública, Universidade Estadual Paulista “Júlio de Mesquita Filho”, Botucatu, 18610-000 São Paulo, Brazil
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Agence Nationale de sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, 06902 Sophia Antipolis, France
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Instituto de Química, Universidade de São Paulo, 05508-000 São Paulo, Brazil
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Departamento de Medicina Veterinária Preventiva e Saúde Animal, Universidade de São Paulo, São Paulo, 05508-270 São Paulo, Brazil
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(1), 30; https://doi.org/10.3390/pathogens9010030
Received: 21 November 2019 / Revised: 22 December 2019 / Accepted: 23 December 2019 / Published: 28 December 2019
(This article belongs to the Special Issue Q Fever)
Coxiella burnetii, the zoonotic agent of Q fever, has a worldwide distribution. Despite the vast information about the circulating genotypes in Europe and North America, there is a lack of data regarding C. burnetii strains in South America. Here, we show the presence of novel multispacer sequence typing (MST) genotypes of C. burnetii in two clusters detected in Brazil and Argentina that seem to be distant in parenthood. Argentinian strains isolated from a tick belongs to a new phylogenetic branch of C. burnetii, and the Brazilians strains may be related to MST 20 and 61. Multilocus variable number tandem repeats analysis (MLVA) typing provided a deeper resolution that may be related to host clusters of bovines, caprine, ovine, and ticks. Our results corroborate with the reports of geotypes of C. burnetii. Thus, we highlight the need for more genotyping studies to understand the genetic diversity of C. burnetii in South America and to confirm the hypothesis of host-related genotypes. We also emphasize the importance of virulence studies for a better understanding of Q fever in the region, which may help in surveillance and disease prevention programs. View Full-Text
Keywords: Coxiella burnetii; Q fever; multilocus sequence typing (MST); tandem repeatsequences Coxiella burnetii; Q fever; multilocus sequence typing (MST); tandem repeatsequences
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Mioni, M.S.R.; Sidi-Boumedine, K.; Morales Dalanezi, F.; Fernandes Joaquim, S.; Denadai, R.; Reis Teixeira, W.S.; Bahia Labruna, M.; Megid, J. New Genotypes of Coxiella burnetii Circulating in Brazil and Argentina. Pathogens 2020, 9, 30.

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