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Volume 8
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10.3390/pathogens8040249
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Article

From Stable to Lab—Investigating Key Factors for Sudden Deaths Caused by Streptococcus suis

by
Isabel Hennig-Pauka
1,
Rabea Imker
2,3,
Leonie Mayer
4,
Michael Brügmann
5,
Christiane Werckenthin
5,
Heike Weber
6,
Andrea Menrath
1 and
Nicole de Buhr
2,3,*
1
Field Station for Epidemiology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany
2
Department of Physiological Chemistry, University of Veterinary Medicine Hannover, 30559 Hannover, Germany
3
Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, 30559 Hannover, Germany
4
Institute of Bacteriology and Mycology, Centre for Infectious Diseases, Veterinary Faculty, University of Leipzig, 04109 Leipzig, Germany
5
Food and Veterinary Institute Oldenburg, Lower Saxony State Office for Consumer Protection and Food Safety, 26029 Oldenburg, Germany
6
Tierpark Nordhorn, 48531 Nordhorn, Germany
*
Author to whom correspondence should be addressed.
Pathogens 2019, 8(4), 249; https://doi.org/10.3390/pathogens8040249
Submission received: 30 September 2019 / Revised: 13 November 2019 / Accepted: 16 November 2019 / Published: 20 November 2019
(This article belongs to the Special Issue Update on Streptococcus suis Research and Prevention in the Era of Antibiotic Restriction - 4th International Workshop on Streptococcus suis)
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Abstract

Swine stocks are endemically infected with the major porcine pathogen Streptococcus (S.) suis. The factors governing the transition from colonizing S. suis residing in the tonsils and the exacerbation of disease have not yet been elucidated. We analyzed the sudden death of fattening pigs kept under extensive husbandry conditions in a zoo. The animals died suddenly of septic shock and showed disseminated intravascular coagulopathy. Genotypic and phenotypic characterizations of the isolated S. suis strains, a tonsillar isolate and an invasive cps type 2 strain, were conducted. Isolated S. suis from dead pigs belonged to cps type 2 strain ST28, whereas one tonsillar S. suis isolate harvested from a healthy animal belonged to ST1173. Neither S. suis growth, induction of neutrophil extracellular traps, nor survival in blood could explain the sudden deaths. Reconstituted blood assays with serum samples from pigs of different age groups from the zoo stock suggested varying protection of individuals against pathogenic cps type 2 strains especially in younger pigs. These findings highlight the benefit of further characterization of the causative strains in each case by sequence typing before autologous vaccine candidate selection.
Keywords: Streptococcus suis; sudden death; DIC; NETs; immune reaction Streptococcus suis; sudden death; DIC; NETs; immune reaction

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MDPI and ACS Style

Hennig-Pauka, I.; Imker, R.; Mayer, L.; Brügmann, M.; Werckenthin, C.; Weber, H.; Menrath, A.; de Buhr, N. From Stable to Lab—Investigating Key Factors for Sudden Deaths Caused by Streptococcus suis. Pathogens 2019, 8, 249. https://doi.org/10.3390/pathogens8040249

AMA Style

Hennig-Pauka I, Imker R, Mayer L, Brügmann M, Werckenthin C, Weber H, Menrath A, de Buhr N. From Stable to Lab—Investigating Key Factors for Sudden Deaths Caused by Streptococcus suis. Pathogens. 2019; 8(4):249. https://doi.org/10.3390/pathogens8040249

Chicago/Turabian Style

Hennig-Pauka, Isabel, Rabea Imker, Leonie Mayer, Michael Brügmann, Christiane Werckenthin, Heike Weber, Andrea Menrath, and Nicole de Buhr. 2019. "From Stable to Lab—Investigating Key Factors for Sudden Deaths Caused by Streptococcus suis" Pathogens 8, no. 4: 249. https://doi.org/10.3390/pathogens8040249

APA Style

Hennig-Pauka, I., Imker, R., Mayer, L., Brügmann, M., Werckenthin, C., Weber, H., Menrath, A., & de Buhr, N. (2019). From Stable to Lab—Investigating Key Factors for Sudden Deaths Caused by Streptococcus suis. Pathogens, 8(4), 249. https://doi.org/10.3390/pathogens8040249

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