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Manipulation of Innate and Adaptive Immunity by Staphylococcal Superantigens
Open AccessArticle

Modulation of the Antibiotic Activity by the Mauritia flexuosa (Buriti) Fixed Oil against Methicillin-Resistant Staphylococcus Aureus (MRSA) and Other Multidrug-Resistant (MDR) Bacterial Strains

1
Technology Center, Laboratory Analysis Physical Chemistry of Food, Faculty of Technology Cariri, Juazeiro do Norte 63041-190, Brazil
2
Department of Biological Chemistry, Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato, CE 63105-000, Brazil
3
Department of Biological Chemistry, Laboratory of Research in Natural Products, Regional University of Cariri, Crato, CE 63105-000, Brazil
4
Department of Biological Chemistry, Laboratory of Pharmacology and Molecular Chemistry, Regional University of Cariri, Crato, CE 63105-000, Brazil
*
Author to whom correspondence should be addressed.
Pathogens 2018, 7(4), 98; https://doi.org/10.3390/pathogens7040098
Received: 19 October 2018 / Revised: 3 December 2018 / Accepted: 6 December 2018 / Published: 10 December 2018
(This article belongs to the Special Issue Molecular Pathogenesis of Staphylococcal Infections)
Mauritia flexuosa (buriti) is a typical Brazilian palm tree found in swampy regions with many plant forms. The fruit has various purposes with the pulps to the seeds being used for ice creams, sweets, creams, jellies, liqueurs, and vitamin production. A physicochemical characterization of the fixed pulp oil and its antibacterial and aminoglycoside antibiotic modifying activity against Gram-positive and Gram-negative multiresistant bacterial strains were performed using broth microdilution assays. Physical properties, such as moisture, pH, acidity, peroxide index, relative density, and refractive index, indicated oil stability and chemical quality. In the GC/MS chemical composition analysis, a high content of unsaturated fatty acids (89.81%) in relation to saturated fatty acids (10.19%) was observed. Oleic acid (89.81%) was the main fatty acid identified. In the antibacterial test, the fixed oil obtained the Minimum Inhibitory Concentration (MIC) ≥ 1024 μg/mL for all standard and multiresistant bacterial strains. The synergic effect of fixed pulp oil combined was observed only in Staphylococcus aureus SA–10, with an MIC reduction of the gentamicin and amikacin by 40.00% and 60.55%, respectively. The data indicates the M. flexuosa fixed oil as a valuable source of oleic acid and modulator of aminoglycoside activity. View Full-Text
Keywords: buriti; fatty acid; antibacterial; aminoglycosides buriti; fatty acid; antibacterial; aminoglycosides
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Faustino Pereira, Y.; Do Socorro Costa, M.; Relison Tintino, S.; Esmeraldo Rocha, J.; Fernandes Galvão Rodrigues, F.; De Sá Barreto Feitosa, M.K.; De Menezes, I.R.A.; Douglas Melo Coutinho, H.; Da Costa, J.G.M.; De Sousa, E.O. Modulation of the Antibiotic Activity by the Mauritia flexuosa (Buriti) Fixed Oil against Methicillin-Resistant Staphylococcus Aureus (MRSA) and Other Multidrug-Resistant (MDR) Bacterial Strains. Pathogens 2018, 7, 98.

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