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Review

What Could Be the Role of Antifungal Lock-Solutions? From Bench to Bedside

by 1,2,* and 2,3,4
1
Laboratory of Ecology and Biology of Interactions, University of Poitiers, UMR CNRS 7267, F-86073 Poitiers, France
2
Faculty of Medicine and Pharmacy, University of Poitiers, F-86073 Poitiers, France
3
CHU Poitiers, Infectious and Tropical Disease Unit, F-86073 Poitiers, France
4
INSERM U1070, F-86073 Poitiers, France
*
Author to whom correspondence should be addressed.
Pathogens 2018, 7(1), 6; https://doi.org/10.3390/pathogens7010006
Received: 28 November 2017 / Revised: 2 January 2018 / Accepted: 3 January 2018 / Published: 6 January 2018
(This article belongs to the Special Issue Pathogenesis and Virulence of Candida albicans and Candida glabrata)
Candidemia related to the presence of a biofilm are often reported in patients with vascular catheters. Once they are mature, biofilms are persistent infectious reservoirs, and the yeasts dispersed from biofilms can cause infections. Sessile yeasts typically display increased levels of resistance to most antimicrobial agents and systemic treatments usually fail to eradicate previously formed fungal biofilms. In a curative strategy, antifungal lock therapy may help to sterilize catheters, with very high concentrations of antifungal agents, which are not compatible with systemic use. This strategy has been studied by several authors in in vitro and in vivo studies, and more rarely, in clinical settings for adult and paediatric patients. Our study aims to assess the efficacy of the antifungal solutions used for lock therapy and demonstrated by the different teams. View Full-Text
Keywords: biofilm; antifungal agents; candidemia; catheter carrier patient biofilm; antifungal agents; candidemia; catheter carrier patient
MDPI and ACS Style

Imbert, C.; Rammaert, B. What Could Be the Role of Antifungal Lock-Solutions? From Bench to Bedside. Pathogens 2018, 7, 6. https://doi.org/10.3390/pathogens7010006

AMA Style

Imbert C, Rammaert B. What Could Be the Role of Antifungal Lock-Solutions? From Bench to Bedside. Pathogens. 2018; 7(1):6. https://doi.org/10.3390/pathogens7010006

Chicago/Turabian Style

Imbert, Christine, and Blandine Rammaert. 2018. "What Could Be the Role of Antifungal Lock-Solutions? From Bench to Bedside" Pathogens 7, no. 1: 6. https://doi.org/10.3390/pathogens7010006

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